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Pharmacology Lecture

Research room overview

Using “relief from pain” as a key word, we have studied to reveal the pain control system and mechanism of tolerance and dependence development caused by opioids. Recently, we have developed research with themes of “involvement of neuroinflammation in the pathology of neuropathic pain,” “evaluation of the physiological function of nicotine and its therapeutic application to diseases,” and “clarifications of tolerance and dependence development caused by addictive drugs.”

Education overview

We provide primary knowledge of the in-vitro mechanism of drugs, including “mechanism at individual cell level” and “factors affecting efficacy.” We provide education aiming to train healthcare professionals who fully understand and apply the pharmacology and adverse effects of drugs used to treat, diagnose, and prevent.

Subjects taught in this research room

School of Medicine	Living Organisms and Drugs, Pharmacology Training, and Basic Medicine Problem-based Learning (PBL)
School of Health and Nursing Science	Basic Pharmacology, and Clinical Pharmacology
Subjects common throughout the graduate school	Introduction to Pharmacology, and Introduction to Medical Science Research Method

Research summaries and achievements (from 2007)

Research themes
Original article
Books・Review
Other

Kiguchi N, Sukhtankar DD, Ding H, Tanaka K, Kishioka S, Peters CM, Ko MC:
Spinal functions of B-type natriuretic peptide, gastrin-releasing peptide, and their cognate receptors for regulating itch in mice.
J Pharmacol Exp Ther 2016; 356(3): 596-603.
Kiguchi N, Saika F, Kobayashi Y, Ko MC, Kishioka S:
TC-2559, an a・b・ nicotinic acetylcholine receptor agonist, suppresses the expression of CCL3 and IL-1β through STAT3 inhibition in cultured murine macrophages.
J Pharmacol Sci 2015; 128(2): 83-86.
Kobayashi Y, Kiguchi N, Fukazawa Y, Saika F, Maeda T, Kishioka S:
Macrophage-T cell interactions mediate neuropathic pain through the glucocorticoid-induced tumor necrosis factor ligand system.
J Biol Chem 2015; 290(20): 12603-12613.
Kiguchi N, Kobayashi Y, Saika F, Sakaguchi H, Maeda T, Kishioka S:
Peripheral interleukin-4 ameliorates inflammatory macrophage-dependent neuropathic pain.
Pain 2015; 156(4): 684-693.
Saika F, Kiguchi N, Kobayashi Y, Kishioka S:
Peripheral alpha4beta2 nicotinic acetylcholine receptor signaling attenuates tactile allodynia and thermal hyperalgesia after nerve injury in mice.
Acta Physiol 2015; 213(2): 462-471.
小林悠佳、岸岡史郎：
新規疼痛制御分子としてのマクロファージ由来マトリックスメタロプロテアーゼ12 の可能性
PAIN RESEARCH 2015; 30(1): 37-45.
Wakida N, Kiguchi N, Saika F, Nishiue H, Kobayashi Y, Kishioka S:
CC-chemokine ligand 2 facilitates conditioned place preference to methamphetamine through the activation of dopamine systems.
J Pharmacol Sci 2014; 125(1): 68-73.
Kiguchi N, Kobayashi Y, Kadowaki Y, Fukazawa Y, Saika F, Kishioka S:
Vascular endothelial growth factor signaling in injured nerves underlies peripheral sensitization in neuropathic pain.
J Neurochem 2014; 129(1): 169-178.
Ueno K, Kiguchi N, Kobayashi Y, Saika F, Wakida N, Yamamoto C, Maeda T, Ozaki M, Kishioka S:
Possible involvement of endogenous opioid system located downstream of a・ nicotinic acetylcholine receptor in mice with physical dependence on nicotine.
J Pharmacol Sci 2014; 124(1): 47-53.
Kiguchi N, Kobayashi Y, Saika F, Kishioka S:
Epigenetic upregulation of CCL2 and CCL3 via histone modifications in infiltrating macrophages after peripheral nerve injury.
Cytokine 2013; 64(3): 666-672.
Kishioka S, Kiguchi N, Kobayashi Y, Yamamoto C, Saika F, Wakida N, Ko MC, Woods JH:
Pharmacokinetic evidence for the long-lasting effect of nor-binaltorphimine, a potent kappa opioid receptor antagonist, in mice.
Neurosci Lett 2013; 552: 98-102.
Kiguchi N, Kobayashi Y, Maeda T, Tominaga S, Nakamura J, Fukazawa Y, Ozaki M, Kishioka S:
Activation of nicotinic acetylcholine receptors on bone marrow-derived cells relieves neuropathic pain accompanied by peripheral neuroinflammation.
Neurochem Int 2012; 61(7): 1212-1219.
Kobayashi Y, Kiguchi N, Maeda T, Ozaki M, Kishioka S:
The critical role of spinal ceramide in the development of partial sciatic nerve ligation-induced neuropathic pain in mice.
Biochem Biophys Res Commun 2012; 421(2): 318-322.
Saika F, Kiguchi N, Kobayashi Y, Fukazawa Y, Kishioka S:
CC-chemokine ligand 4/macrophage inflammatory protein-1beta participates in the induction of neuropathic pain after peripheral nerve injury.
Eur J Pain 2012; 16(9): 1271-1280.
Kiguchi N, Kobayashi Y, Maeda T, Fukazawa Y, Tohya K, Kimura M, Kishioka S:
Epigenetic augmentation of the MIP-2/CXCR2 axis through histone H3 acetylation in injured peripheral nerves elicits neuropathic pain.
J Pharmacol Exp Ther 2012; 340(3): 577-587.
Iwai S, Kiguchi N, Kobayashi Y, Fukazawa Y, Saika F, Ueno K, Yamamoto C, Kishioka S:
Inhibition of morphine tolerance is mediated by painful stimuli via central mechanisms.
Drug Discov Ther 2012; 6(1): 31-37.
Nishiyori M, Uchida H, Nagai J, Araki K, Mukae T, Kishioka S and Ueda H:
Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants.
Mol Pain 2011; 7: 69-78.
Nawa A, Fujita-Hamabe W, Kishioka S and Tokuyama S:
Decreased expression of intestinal P-glycoprotein increases the analgesic effects of oral morphine in streptozotocin-induced diabetic mouse model.
Drug Metab Pharmacokinet 2011; 26(6): 584-591.
Yamamoto A, Kiguchi N, Kobayashi Y, Maeda T, Ueno K, Yamamoto C, Kishioka S:
Pharmacological relationship between nicotinic and opioid systems in analgesia and corticosterone elevation.
Life Sci 2011; 89: 956-961.
Ueno K, Maeda T, Kiguchi N, Kobayashi Y, Ozaki M, Kishioka S:
Availability of serum corticosterone level for quantitative evaluation of morphine withdrawal in mice.
Drug Discov Ther 2011; 5(2): 71-75.
Kiguchi N, Kobayashi Y, Maeda T, Saika F, Kishioka S:
CC-chemokine MIP-1alpha in the spinal cord contributes to nerve injury-induced neuropathic pain.
Neurosci Lett 2010; 484: 17-21.
Maeda T, Kiguchi N, Kobayashi Y, Ozaki M, Kishioka S:
Increment of activated serine/threonine protein phosphatase in brain membrane fraction synchronized with antinociceptive effect of morphine in mice.
Biol Pharm Bull 2010; 33 (6): 1011-1014.
Kiguchi N, Maeda T, Kobayashi Y, Fukazawa Y, Kishioka S:
Macrophage inflammatory protein-1alpha mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1beta up-regulation.
Pain 2010; 149(2): 305-315.
Maeda T, Kiguchi N, Kobayashi Y, Ikuta T, Ozaki M, Kishioka S:
Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation.
Proc Natl Acad Sci USA 2009; 106(31): 13076-13081.
Kiguchi N, Maeda T, Kobayashi Y, Fukazawa Y, Kishioka S:
Activation of extracellular signal-regulated kinase in sciatic nerve contributes to neuropathic pain following partial sciatic nerve ligation in mice.
Anesth Analg 2009; 109(4): 1305-1311.
Kumamoto K, Hirai T, Kishioka S, Iwahashi H:
Identification of radicals formed in the reaction mixture of bovine kidney microsomes with NADPH.
J Biochem 2009; 146(4): 571-579.
Saika F, Kiguchi N, Kobayashi Y, Fukazawa Y, Maeda T, Ozaki M, Kishioka S:
Suppressive effect of imipramine on vincristine-induced mechanical allodynia in mice.
Biol Pharm Bull 2009; 32(7): 1231-1234.
Kiguchi N, Maeda T, Kobayashi Y, Fukazawa Y, Kishioka S:
Leptin enhances CC-chemokine ligand expression in cultured murine macrophage.
Biochem Biophys Res Commun 2009; 384(3): 311-315.
Shang L, Fang H, Zhu H, Wang X, Wang Q, Mu J, Wang B, Kishioka S, Xu W:
Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors.
Bioorg Med Chem 2009; 17(7): 2775-2784.
Iwai S, Maeda T, Kiguchi N, Kobayashi Y, Fukazawa Y, Ozaki M, Kishioka S:
Pioglitazone attenuates tactile allodynia and microglial activation in mice with peripheral nerve injury.
Drug Discov Ther 2008; 2(6), 353-356.
Maeda T, Kiguchi N, Kobayashi Y, Ozaki M, Kishioka S:
Pioglitazone attenuates tactile allodynia and thermal hyperalgesia in mice subjected to peripheral nerve injury.
J Pharmacol Sci 2008; 108(3): 341-347.
Kiguchi N, Maeda T, Kobayashi Y, Kishioka S:
Up-regulation of tumor necrosis factor-alpha in spinal cord contributes to vincristine-induced mechanical allodynia in mice.
Neurosci Lett 2008; 445: 140-143.
Kiguchi N, Maeda T, Kobayashi Y, Kondo T, Ozaki M, Kishioka S: The critical role of invading peripheral macrophage-derived interleukin-6 in vincristine-induced mechanical allodynia in mice.
Eur J Pharmacol 2008; 592(1-3): 87-92.
Kiguchi N, Maeda T, Tsuruga M, Yamamoto A, Yamamoto C, Ozaki M, Kishioka S:
Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice.
Brain Res 2008; 1189: 70-77.
Shang L, Maeda T, Xu W and Kishioka S:
Evaluation of a novel aminopeptidase N inhibitor, in vitro, using two assay systems.
J Enzyme Inhib Med Chem 2008; 23(2): 198-205.
Hamabe W, Maeda T, Kiguchi N, Yamamoto C, Tokuyama S, Kishioka S:
Negative relationship between morphine analgesia and P-glycoprotein expression levels in brain.
J Pharmacol Sci 2007; 105 (4): 353-360.
Fukazawa Y, Maeda T, Kiguchi N, Tohya K, Kimura M, Kishioka S:
Activation of spinal cholecystokinin and neurokinin1 receptors is associated with the attenuation of intrathecal morphine analgesia following electroacupuncture stimulation in rats.
J Pharmacol Sci 2007; 104 (2): 159-166.
Maeda T, Kiguchi N, Fukazawa Y, Yamamoto A, Ozaki M, Kishioka S:
Peroxisome proliferator-activated receptor gamma activation relieves expression of behavioral sensitization to methamphetamine in mice.
Neuropsychopharmacology 2007; 32(5): 1133-1140.

雑賀史浩、木口倫一、岸岡史郎：
The role of CC-chemokine ligand 2 in the development of psychic dependence on methamphetamine.
日本アルコール薬物医学会雑誌 2015; 50(5): 189-195.
小林悠佳、木口倫一、雑賀史浩、岸岡史郎：
Exploration of novel therapeutic targets for neuropathic pain based on the regulation of immune cells.
日本神経精神薬理学雑誌 2015; 35(3): 65-72.
岸岡史郎、木口倫一、小林悠佳、雑賀史浩、山本千鶴子：
The development of physical dependence on nicotine and endogenous opioid system--participation of alpha7 nicotinic acetylcholine receptor.
日本アルコール薬物医学会雑誌 2014; 49(5): 227-237.
Kiguchi N, Saika F, Kobayashi Y, Kishioka S:
Epigenetic regulation of CC-chemokine ligand 2 in nonresolving inflammation.
Biomol Concepts 2014; 5(4): 265-273.
Kishioka S, Kiguchi N, Kobayashi Y, Saika F:
Nicotine effects and the endogenous opioid system.
J Pharmacol Sci 2014; 125(2): 117-124.
Maeda T, Ozaki M, Kobayashi Y, Kiguchi N, Kishioka S:
HMGB1 as a potential therapeutic target for neuropathic pain.
J Pharmacol Sci; in press
木口倫一：
炎症性ケモカインによる慢性神経炎症を介した神経障害性疼痛形成の分子基盤
和歌山医学、63(3)、98-103、和歌山医学会、2012年9月
Kiguchi N, Kobayashi Y, Kishioka S:
Chemokines and cytokines in neuroinflammation leading to neuropathic pain.
Curr Opin Pharmacol 2012; 12(1): 55-61.
木口倫一、岸岡史郎：
神経炎症が関与する末梢神経障害性疼痛のメカニズム
ペインクリニック、32 (10)、pp1499-1509、真興交易（株）、2011年10月
前田武彦:
レプチンと神経障害性疼痛,
医学のあゆみ, 233(7), pp. 565, 2010.
前田武彦:
覚せい剤精神病および覚せい剤依存の基礎研究における現状,
和歌山医学, 61(2), pp. 36-41, 2010.
Kiguchi N, Maeda T, Kobayashi Y, Saika F, Kishioka S:
Involvement of inflammatory mediators in neuropathic pain caused by vincristine.
Int Rev Neurobiol 2009; 85: 179-190.
Maeda T, Kishioka S: PPAR and pain.
Int Rev Neurobiol 2009; 85: 165-177.
Fukazawa Y, Maeda T, Kishioka S:
The pharmacological mechanisms of electroacupuncture.
Curr Opin Investig Drugs 2009; 10(1): 62-69.
Toda N, Kishioka S, Hatano Y, Toda H:
Interactions between morphine and nitric oxide in various organs.
J Anesth 2009; 23: 554-568.
Toda N, Kishioka S, Hatano Y, Toda H:
Modulation of opioid actions by nitric oxide signaling.
Anesthesiology 2009; 110(1): 166-181.
濱邊和歌子, 前田武彦, 徳山尚吾, 岸岡史郎:
モルヒネの抗侵害刺激効果におけるP糖蛋白質の発現量およびATPase活性の関与,
ペインクリニック, 29, pp. 331-338, 新興交易, 2008.
岸岡史郎: 神経伝達物質（分担訳）, pp. 105-133, 第II部ニューロン「エッセンシャル神経科学」前田正信　監訳, 丸善, 2008.
前田武彦, 岸岡史郎: シナプス伝達（分担訳）, pp. 94-104, 第II部ニューロン「エッセンシャル神経科学」前田正信　監訳, 丸善, 2008.
岸岡史郎: オピオイド鎮痛薬と拮抗薬, pp. 669- 728, グッドマン・ギルマン薬理書［上］薬物治療の基礎と臨床（分担訳者）第11版, 高折修二, 福田英臣, 赤池昭紀, 石井邦雄　監訳, 広川書店, 2007.
岸岡史郎: 血液脳関門, pp. 10-13, コアカリ対応　よくわかる病態生理８　神経疾患, 前田正信　編, 日本医事新報社, 東京, 2007.

前田正信, 向阪彰, 岸岡史郎, 岩橋秀夫, 池田裕明, 竹下達也, 宮下和久, 有田幹雄, 冨田耕太郎, 和気秀文: 柿による悪酔い防止の生理学的研究, 自律神経, 47 (1), 32-38, 2010.
早野泰造, 岸岡史郎, 山本博之, 生駒芳久: 計算化学から見た薬物の特性 (9)抗てんかん薬, 和歌山医学, 58 (4), 181-184, 2007.
早野泰造, 岸岡史郎, 山本博之, 生駒芳久: 計算化学から見た薬物の特性 (8)Benzodiazepines, 和歌山医学, 58 (4), 185-187, 2007.

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Pharmacology Lecture

Research room overview

Education overview

Subjects taught in this research room

Research summaries and achievements (from 2007)

Undergraduate