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大 脳皮質の発生
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[原著]

Satake T, Otsuki K, Banba Y, Suenaga J, Hirano H, Yamanaka Y, Ohno S, Hirai S.
The interaction of Kinesin-1 with its adaptor protein JIP1 can be regulated via proteins binding to the JIP1-PTB domain.

BMC Cell Biol. 14:12 (2013).


Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L Jr, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai S, Germain L, Simard-Bisson C, Blouin R, Nguyen JV, Davis CH, Enke RA, Boye SL, Merbs SL, Marsh-Armstrong N, Hauswirth WW, DiAntonio A, Nickells RW, Inglese J, Hanes J, Yau KW, Quigley HA, Zack DJ.

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.
Proc Natl Acad Sci U S A. 110:4045-50 (2013).


Kimura J, Ono HA, Kosaka T, Nagashima Y, Hirai S, Ohno S, Aoki K, Julia D, Yamamoto M, Kunisaki C, Endo I.

Conditionally replicative adenoviral vectors for imaging the effect of chemotherapy on pancreatic cancer cells.

Cancer Sci. 104:1083-90 (2013).


Hayashi K, Suzuki A, Hirai S, Kurihara Y, Hoogenraad CC, Ohno S.

Maintenance of dendritic spine morphology by partitioning-defective 1b through regulation of microtubule growth.

J Neurosci. 31:12094-103 (2011).


Hirai S
, Banba Y, Satake T, Ohno S.
Axon formation in neocortical neurons depends on stage-specific regulation of microtubule stability by the dual leucine zipper kinase-c-Jun N-terminal kinase pathway.

J Neurosci. 31:6468-80 (2011).


Jin J, Suzuki H, Hirai S, Mikoshiba K, Ohshima T.
JNK phosphorylates Ser332 of doublecortin and regulates its function in neurite extension and neuronal migration.

Dev Neurobiol. 70:929-42 (2010).


Saitsu H, Tohyama J, Kumada T, Egawa K, Hamada K, Okada I, Mizuguchi T, Osaka H, Miyata R, Furukawa T, Haginoya K, Hoshino H, Goto T, Hachiya Y, Yamagata T, Saitoh S, Nagai T, Nishiyama K, Nishimura A, Miyake N, Komada M, Hayashi K, Hirai S, Ogata K, Kato M, Fukuda A, Matsumoto N.
Dominant-negative mutations in alpha-II spectrin cause West syndrome with severe cerebral hypomyelination, spastic quadriplegia, and developmental delay.

Am J Hum Genet. 86:881-91 (2010).


Saitsu H, Kato M, Mizuguchi T, Hamada K, Osaka H, Tohyama J, Uruno K, Kumada S, Nishiyama K, Nishimura A, Okada I, Yoshimura Y, Hirai S, Kumada T, Hayasaka K, Fukuda A, Ogata K, Matsumoto N.
De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy.

Nat Genet. 40:782-8 (2008).


Zhao W, Hirose T, Ishikawa M, Oshima Y, Hirai S, Ohno S, Taniguchi H.
Neonatal pancreatic cells redifferentiate into both neural and pancreatic lineages.

Biochem Biophys Res Commun. 352:84-90 (2007).


Yamashita N, Uchida Y, Ohshima T, Hirai S, Nakamura F, Taniguchi M, Mikoshiba K, Honnorat J, Kolattukudy P, Thomasset N, Takei K, Takahashi T, Goshima Y.
Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration.

J Neurosci. 26:13357-62 (2006).


Hirai S, Cui de F, Miyata T, Ogawa M, Kiyonari H, Suda Y, Aizawa S, Banba Y, Ohno S.
The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex.

J Neurosci. 26:11992-2002 (2006).


Imai F, Hirai S, Akimoto K, Koyama H, Miyata T, Ogawa M, Noguchi S, Sasaoka T, Noda T, Ohno S.
Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex.

Development. 133:1735-44 (2006).


Suenaga J, Cui de F, Yamamoto I, Ohno S, Hirai S.
Developmental changes in the expression pattern of the JNK activator kinase MUK/DLK/ZPK and active JNK in the mouse cerebellum.

Cell Tissue Res. 325:189-95 (2006).


Renal cell carcinoma- and pheochromocytoma-specific altered gene expression profiles in VHL mutant clones.
Tsuchiya MI, Okuda H, Takaki Y, Baba M, Hirai S, Ohno S, Shuin T.

Oncol Rep. 13:1033-41 (2005).


Hirai S, Kawaguchi A, Suenaga J, Ono M, Cui DF, Ohno S.
Expression of MUK/DLK/ZPK, an activator of the JNK pathway, in the nervous systems of the developing mouse embryo.

Gene Expr Patterns. 5:517-23 (2005).


Hirai S, Kawaguchi A, Hirasawa R, Baba M, Ohnishi T, Ohno S.
MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo.

Development. 129:4483-95 (2002).


Manabe N, Hirai S, Imai F, Nakanishi H, Takai Y, Ohno S.
Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells.

Dev Dyn. 225:61-9 (2002).

                                



[総説]

平井秀一
大脳皮質発生とMAPキナーゼ

Clinical Neuroscience 31, No.6, 679-681 (2013)

平井秀一
軸索形成に必要なDLK-JNK経路と微小管制御
生体の科学 63, No.3, 183-188 (2012)

平井秀一

がん細胞を知る−分子レベルでみた正常細胞との違い−
Medical Technology 38, No.5, 503-506 (2010)

平井秀一、大野茂男
EMTにおける細胞極性の転換
細胞工学 27, No.4, 326-331 (2008).

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大脳皮質の発生
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