Publications

2024

  • "Modular synthetic strategy for N/C-terminal protected amyloidogenic peptides"

    Taka Sawazaki, Youhei Sohma
    J. Peptide Sci. (Special issue: PeptideTalents), 2024, 30, e3546. DOI:10.1002/psc.3546

2023

  • "Photo-oxygenation of histidine residue inhibits α-synuclein aggregation"

    Reito Nakamura, Ikumi Tomizawa, Atsushi Iwai, Tetsuo Ikeda, Kota Hirayama, Yung Wen Chiu, Takanobu Suzuki, Airi Tarutani, Tatsuo Mano, Atsushi Iwata, Tatsushi Toda, Youhei Sohma, Motomu Kanai, Yukiko Hori, Taisuke Tomita
    FASEB Journal, 2023, 37, e23311. DOI:10.1096/fj.202301533R

  • "Rose bengal promoted catalytic amyloid-β oxygenation via sono-activation"

    Wataru Atsumi, Keiichi Kawabata, Mina Yamane, Miku Oi, Harunobu Mitsunuma, Youhei Sohma, Yukiko Hori, Taisuke Tomita, Motomu Kanai
    Synlett (Special Issue dedicated to Keith Fagnou), 2023. DOI:10.1055/a-2182-7614

  • "Quantitative assays for catalytic photo-oxygenation of Alzheimer disease-related tau proteins"

    Hiroki Umeda, Taka Sawazaki, Masahiro Furuta, Takanobu Suzuki, Shigehiro A. Kawashima, Harunobu Mitsunuma, Yukiko Hori, Taisuke Tomita, Youhei Sohma, Motomu Kanai
    ACS Chemical Neuroscience, 2023, 14, 2710-2716. DOI:10.1021/acschemneuro.3c00264

  • Contributing to Society Newsletter"これまでの研究活動を一旦振り返って"

    相馬洋平
    日本ペプチド学会　ニュースレター　No. 128（2023年4月） https://www.peptide-soc.jp/files/newsletter/PNJ128.pdf

  • "Attenuation of α-synuclein aggregation by catalytic photo-oxygenation"

    Atsushi Iwai, Reito Nakamura, Ikumi Tomizawa, Harunobu Mitsunuma, Yukiko Hori, Taisuke Tomita, Youhei Sohma, Motomu Kanai
    Chem. Commun., 2023, 59, 5745-5748. DOI:10.1039/D3CC00665D

2022

  • Article Commentary"Promotion in the Clearance of Aggregated Aβ in vivo using Amyloid Selective Photo-Oxygenation Technology”

    Yukiko Hori, Youhei Sohma, Motomu Kanai, Taisuke Tomita
    Neuroscience Insights, 2022, 17. DOI:10.1177/26331055221126179

  • "Activatable Iodinated BODIPYs for Selective Imaging and Photodynamic Disruption of Amyloid Structures in Pathogenic Bacterial Biofilms"

    Joaquim Torra,Taka Sawazaki, Patricia Bondia, Santi Nonell, Motomu Kanai, Youhei Sohma, Cristina Flors
    Sens. Actuators B Chem., 2022, 132475. DOI:10.1016/j.snb.2022.132475

  • "Single crystal spectroscopy and multiple structures from one crystal (MSOX) define catalysis in copper nitrite reductases"

    Samuel L. Rose, Seiki Baba, Hideo Okumura, Svetlana V. Antonyuk, Daisuke Sasaki, Tobias M. Hedison, Muralidharan Shanmugam, Derren J. Heyes, Nigel S. Scrutton, Takashi Kumasaka, Takehiko Tosha, Robert R. Eady, Masaki Yamamoto, S. Samar Hasnain
    Proc. Natl. Acad. Sci. U.S.A., 2022, 119, e2205664119. DOI:10.1073/pnas.2205664119

  • Review Paper"化学触媒を用いた光酸素化反応による神経変性疾患の治療を目指して"

    相馬洋平，金井求
    生化学, 2022, 94, 406-410. DOI:10.14952/SEIKAGAKU.2022.940406

  • Review Paper"Photo-oxygenation as a new therapeutic strategy for neurodegenerative proteinopathies by enhancing the clearance of amyloid proteins"

    Ikumi Tomizawa, Hanako Nakagawa, Youhei Sohma, Motomu Kanai, Yukiko Hori, Taisuke Tomita
    Front. Aging Neurosci., 2022, 14, 945017 DOI:10.3389/fnagi.2022.945017

  • "Knoevenagel condensation between 2-methyl-thiazolo[4,5-b]pyrazines and aldehydes"

    Taka Sawazaki, Youhei Sohma, Motomu Kanai
    Chem. Pharm. Bull. 2022, 70, 82–84. DOI:10.1248/cpb.c21-00780

2021

  • Review Paper"Chemical catalyst-promoted photooxygenation of amyloid proteins"

    Youhei Sohma, Taka Sawazaki, Motomu Kanai
    Org. Biomol. Chem., 2021, 19, 10017 - 10029. DOI:10.1039/D1OB01677F

  • "Photo-oxygenation by a biocompatible catalyst reduces amyloid-β levels in Alzheimer’s disease mice"

    Shuta Ozawa, Yukiko Hori, Yusuke Shimizu, Atsuhiko Taniguchi, Takanobu Suzuki, Wenbo Wang, Yung Wen Chiu, Reiko Koike, Satoshi Yokoshima, Tohru Fukuyama, Sho Takatori, Youhei Sohma, Motomu Kanai and Taisuke Tomita
    Brain 2021, awab058. DOI:10.1093/brain/awab058

  • "Catalytic photooxygenation degrades brain Aβ in vivo"

    Nozomu Nagashima, Shuta Ozawa, Masahiro Furuta, Miku Oi, Yukiko Hori, Taisuke Tomita, Youhei Sohma and Motomu Kanai
    Sci. Adv. 2021, 7, eabc9750. DOI:10.1126/sciadv.abc9750

Selected papers before 2020

  • "Reverse protein engineering of a novel 4-domain copper nitrite reductase reveals functional regulation by protein–protein interaction"

    Daisuke Sasaki, Tatiana F. Watanabe, Robert R. Eady, Richard C. Garratt, Svetlana V. Antonyuk, S. Samar Hasnain

    The FEBS Journal 2021, 288, 262-280. DOI:10.1111/febs.15324

  • "Structures of substrate- and product-bound forms of a multi-domain copper nitrite reductase shed light on the role of domain tethering in protein complexes"

    Daisuke Sasaki, Tatiana F. Watanabe, Robert R. Eady, Richard C. Garratt, Svetlana V. Antonyuk, S. Samar Hasnain

    IUCrJ, 2020, 7, 557-565. DOI:10.1107/S2052252520005230

  • "Design, synthesis, and properties of a chemically-tethered amyloid-β segment trimer resistant to inter-trimer mis-aggregation"

    Kiyomichi Shinoda, Motomu Kanai and Youhei Sohma

    J. Org. Chem. 2020, 85, 1635-1643. DOI:10.1021/acs.joc.9b02612

  • "Nanoscale View of Amyloid Photodynamic Damage"

    Patricia Bondia, Joaquim Torra, Caterina M. Tone, Taka Sawazaki, Adrián del Valle, Begoña Sot, Santi Nonell, Motomu Kanai, Youhei Sohma, and Cristina Flors

    J. Am. Chem. Soc. 2020, 142, 922-930. DOI:10.1021/jacs.9b10632

    [Cover]

  • "Photo-oxygenation inhibits tau amyloid formation"

    Takanobu Suzuki, Yukiko Hori, Taka Sawazaki, Yusuke Shimizu, Yu Nemoto, Atsuhiko Taniguchi, Shuta Ozawa, Youhei Sohma, Motomu Kanai, Taisuke Tomita
    Chem. Commun. 2019, 55, 6165-6168. DOI:10.1039/C9CC01728C

    [Front cover]

  • "A P-C chelate, protic 1,2-dihydropyridin-2-ylidene Ruthenium complex: synthesis, structure, and reversible deprotonation"

    Naoto Tashima, Taka Sawazaki, Yoshihito Kayaki, Shigeki Kuwata
    Chem. Lett. 2019, 48, 787-790. DOI:10.1246/cl.190253

  • Review Paper"疾患原因アミロイドを選択的に光酸素化する人工触媒の開発"

    相馬洋平, 金井求
    有機合成化学協会誌　2019, 77, 246-253. DOI:10.5059/yukigoseikyokaishi.77.246

  • Review Paper"神経変性疾患治療を目指したアミロイドの光酸素化反応"

    堀由起子, 相馬洋平
    ファルマシア　2019, 55, 532-536. DOI:10.14894/faruawpsj.55.6_532

  • "Convergent and functional-group-tolerant synthesis of B-organo BODIPYs"

    Taka Sawazaki, Yusuke Shimizu, Kounosuke Oisaki, Youhei Sohma, Motomu Kanai
    Org. Lett. 2018, 20, 7767-7770. DOI:10.1021/acs.orglett.8b03138

  • "Hydroxy group directed catalytic hydrosilylation of amides"

    Jizhi Ni, Tsubasa Oguro, Taka Sawazaki, Youhei Sohma, Motomu Kanai
    Org. Lett. 2018, 20, 7371-7374. DOI:10.1021/acs.orglett.8b03014

  • "Near-infrared photoactivatable oxygenation catalysts of amyloid peptide"

    Jizhi Ni, Atsuhiko Taniguchi, Shuta Ozawa, Yukiko Hori, Yoichiro Kuninobu, Takashi Saito, Takaomi C. Saido, Taisuke Tomita, Youhei Sohma, Motomu Kanai
    Chem, 2018, 4, 807-820. DOI:10.1016/j.chempr.2018.02.008

  • Review Paper"天然物化学における新たなペプチド研究を目指して"

    相馬洋平
    有機合成化学協会誌　2018, 76, 466-469. DOI:10.5059/yukigoseikyokaishi.76.466

  • "Scandium(III) triflate-promoted serine/threonine selectivepeptide bond cleavage"

    Jizhi Ni, Youhei Sohma and Motomu Kanai
    Chem. Commun., 2017, 53, 3311-3314. DOI:10.1039/c6cc10300f

  • "Switchable photooxygenation catalysts that sense higher-order amyloid structures"

    Atsuhiko Taniguchi, Yusuke Shimizu, Kounosuke Oisaki, Youhei Sohma, and Motomu Kanai
    Nat. Chem. 2016, 8, 974. DOI:10.1038/nchem.2550

  • Review Paper"Medicinal Chemistry Focusing on Aggregation of Amyloid-β"

    Youhei Sohma
    Chem. Pharm. Bull., 2016, 64, 1. DOI:10.1248/cpb.c15-00742

  • "Rational design and identification of non-peptidic aggregation inhibitor of amyloid-β based on a pharmacophore motif obtained from cyclo[-Lys-Leu-Val-Phe-Phe-]"

    Tadamasa Arai, Takushi Araya, Daisuke Sasaki, Atsuhiko Taniguchi, Takeshi Sato, Youhei Sohma, and Motomu Kanai
    Angew. Chem. Int. Ed. 2014, 53, 8236. DOI:10.1002/anie.201405109

  • "Asparagine-selective cleavage of peptide bonds through hypervalent iodine-mediated hofmann rearrangement in neutral aqueous solution"

    Kana Tanabe, Atsuhiko Taniguchi, Takuya Matsumoto, Kounosuke Oisaki, Youhei Sohma, and Motomu Kanai
    Chem. Sci. 2014, 5, 2747. DOI:10.1039/C3SC53037J

  • "Attenuation of the aggregation and neurotoxicity of amyloid-β peptides by catalytic photooxygenation"

    Atsuhiko Taniguchi, Daisuke Sasaki, Azusa Shiohara, Takeshi Iwatsubo, Taisuke Tomita, Youhei Sohma, and Motomu Kanai
    Angew. Chem. Int. Ed. 2014, 53, 1382. DOI:10.1002/anie.201308001