具体的な研究テーマ

1. タンパク質の糖付加修飾C-／N-マンノシル化の細胞生物機能の解明
2. ERシャペロン・カルレティキュリンの生理機能とEMTにおける役割の解明
3. タンパク質のレドックス「酸化還元」制御による細胞シグナル伝達機構の解明

［英語原著論文と総説］

2024

Tabata S, Yamashita Y, Inai Y, Morita S, Kosako H, Takagi T, Shide K, Manabe S, Matsuoka TA, Shimoda K, Sonoki T, Ihara Y, Tamura S. C-Mannosyl tryptophan is a novel biomarker for thrombocytosis of myeloproliferative neoplasms. Sci Rep., 14, 18858, 2024.

Yamada H, Yamada R, Komohara Y, Mito R, Nishitsuji K, Yano H, Fujiwara Y, Ikeda K, Suzuki M. A Case of Aggressive Lung Squamous Cell Carcinoma With Aberrant Cytoplasmic p53 Aggregation. Cancer Diagn Progn., 4, 204-208, 2024.

Takeda-Uchimura Y, Ikezaki M, Akama TO, Ihara Y, Allain F, Nishitsuji K, Uchimura K. GlcNAc6ST2/CHST4 Is Essential for the Synthesis of R-10G-Reactive Keratan Sulfate/Sulfated N-Acetyllactosamine Oligosaccharides in Mouse Pleural Mesothelium. Molecules., 29, 764, 2024.

Nishitsuji K, Mito R, Ikezaki M, Yano H, Fujiwara Y, Matsubara E, Nishikawa T, Ihara Y, Uchimura K, Iwahashi N, Sakagami T, Suzuki M, Komohara Y. Impacts of cytoplasmic p53 aggregates on the prognosis and the transcriptome in lung squamous cell carcinoma. Cancer Sci., 115, 2947-2960, 2024.

2023

Takechi-Haraya Y, Ohgita T, Usui A, Nishitsuji K, Uchimura K, Abe Y, Kawano R, Konaklieva MI, Reimund M, Remaley AT, Sato Y, Izutsu KI, Saito H. Structural flexibility of apolipoprotein E-derived arginine-rich peptides improves their cell penetration capability. Sci Rep., 13, 19396, 2023.

Namba N, Ohgita T, Tamagaki-Asahina H, Nishitsuji K, Shimanouchi T, Sato T, Saito H. Amyloidogenic 60-71 deletion/ValThr insertion mutation of apolipoprotein A-I generates a new aggregation-prone segment that promotes nucleation through entropic effects. Sci Rep., 13, 18514, 2023.

2022

Uchimura K, Nishitsuji K, Chiu LT, Ohgita T, Saito H, Allain F, Gannedi V, Wong CH, Hung SC. Design and Synthesis of 6-O-Phosphorylated Heparan Sulfate Oligosaccharides to Inhibit Amyloid beta Aggregation. Chembiochem., 23, e202200191, 2022.

Takeda-Uchimura Y, Nishitsuji K, Ikezaki M, Akama TO, Ihara Y, Allain F, Uchimura K. Beta3Gn-T7 Is a Keratan Sulfate beta1,3 N-Acetylglucosaminyltransferase in the Adult Brain. Front Neuroanat., 16, 813841, 2022.

Takeda-Uchimura Y, Ikezaki M, Akama TO, Nishioka K, Ihara Y, Allain F, Nishitsuji K, Uchimura K. Complementary Role of GlcNAc6ST2 and GlcNAc6ST3 in Synthesis of CL40-Reactive Sialylated and Sulfated Glycans in the Mouse Pleural Mesothelium. Molecules., 27, 4543, 2022.

Takechi-Haraya Y, Ohgita T, Kotani M, Kono H, Saito C, Tamagaki-Asahina H, Nishitsuji K, Uchimura K, Sato T, Kawano R, Sakai-Kato K, Izutsu KI, Saito H. Effect of hydrophobic moment on membrane interaction and cell penetration of apolipoprotein E-derived arginine-rich amphipathic alpha-helical peptides. Sci Rep., 12, 4959, 2022.

Nishitsuji K, Ikezaki M, Manabe S, Uchimura K, Ito Y, Ihara Y. Thrombospondin type 1 repeat-derived C-mannosylated peptide attenuates synaptogenesis of cortical neurons induced by primary astrocytes via TGF-beta. Glycoconj J., 39, 701-710, 2022.

Matsukawa H, Ikezaki M, Nishioka K, Iwahashi N, Fujimoto M, Nishitsuji K, Ihara Y, Ino K. Calnexin Is Involved in Forskolin-Induced Syncytialization in Cytotrophoblast Model BeWo Cells. Biomolecules., 12, 1050, 2022.

Iwahashi N, Ikezaki M, Komohara Y, Fujiwara Y, Noguchi T, Nishioka K, Sakai K, Nishio K, Ueda M, Ihara Y, Uchimura K, Ino K, Nishitsuji K. Cytoplasmic p53 aggregates accumulated in p53-mutated cancer correlate with poor prognosis. PNAS Nexus., 1, pgac128, 2022.

Ikezaki M, Nishitsuji K, Matsumura K, Manabe S, Shibukawa Y, Wada Y, Ito Y, Ihara Y. C-Mannosylated tryptophan-containing WSPW peptide binds to actinin-4 and alters E-cadherin subcellular localization in lung epithelial-like A549 cells. Biochimie., 192, 136-146, 2022.

Fujimoto M, Jinnouchi K, Kaku Y, Hirata M, Nishitsuji K, Haga H. Investigation of PRAME expression in lipid-laden and non-lipid-laden cutaneous histiocytes. J Cutan Pathol., 49, 1011-1014, 2022.

El Masri R, Seffouh A, Roelants C, Seffouh I, Gout E, Perard J, Dalonneau F, Nishitsuji K, Noborn F, Nikpour M, Larson G, Cretinon Y, Friedel-Arboleas M, Uchimura K, Daniel R, Lortat-Jacob H, Filhol O, Vives RR. Extracellular endosulfatase Sulf-2 harbors a chondroitin/dermatan sulfate chain that modulates its enzyme activity. Cell Rep., 38, 110516, 2022.

2021

Iwahashi N, Ikezaki M, Fujimoto M, Komohara Y, Fujiwara Y, Yamamoto M, Mizoguchi M, Matsubara K, Watanabe Y, Matsuzaki I, Murata SI, Ihara Y, Ino K, Nishitsuji K. Lipid Droplet Accumulation Independently Predicts Poor Clinical Prognosis in High-Grade Serous Ovarian Carcinoma. Cancers (Basel)., 13, 5251, 2021.

Minakata S, Manabe S, Inai Y, Ikezaki M, Nishitsuji K, Ito Y, Ihara Y. Protein C-Mannosylation and C-Mannosyl Tryptophan in Chemical Biology and Medicine. Molecules., 26, 5258, 2021.

Iwahashi N, Ikezaki M, Nishitsuji K, Yamamoto M, Matsuzaki I, Kato N, Takaoka N, Taniguchi M, Murata SI, Ino K, Ihara Y. Extracellularly Released Calreticulin Induced by Endoplasmic Reticulum Stress Impairs Syncytialization of Cytotrophoblast Model BeWo Cells. Cells., 10, 1305, 2021.

Morita S, Inai Y, Minakata S, Kishimoto S, Manabe S, Iwahashi N, Ino K, Ito Y, Akamizu T, Ihara Y. Quantification of serum C-mannosyl tryptophan by novel assay to evaluate renal function and vascular complications in patients with type 2 diabetes. Sci Rep., 11, 1946, 2021.

Iwahashi N, Ikezaki M, Saito H, Uchimura K, Nishitsuji K. Cell-to-cell transmission of p53 aggregates: a novel player in oncology? Mol Cell Oncol., 8, 1892444, 2021.

Ohgita T, Furutani Y, Nakano M, Hattori M, Suzuki A, Nakagawa M, Naniwa S, Morita I, Oyama H, Nishitsuji K, Kobayashi N, Saito H, Novel conformation‐selective monoclonal antibodies against apoA‐I amyloid fibrils, FEBS J., 288, 1496-1513, 2021.

Nishitsuji K, Uchimura K, Contribution of Sulfated Glycosaminoglycans to the Pathology of Amyloidosis. Trends in Glycoscience and Glycotechnology., 33, E141-E145, 2021.

2020

Iwahashi N, Ikezaki M, Nishikawa T, Namba N, Ohgita T, Saito H, Ihara Y, Shimanouchi T, Ino K, Uchimura K, Nishitsuji K, Sulfated glycosaminoglycans mediate prion-like behavior of p53 aggregates. Proc Natl Acad Sci U S A., 117, 33225-33234, 2020.

Minakata S, Inai Y, Manabe S, Nishitsuji K, Ito Y, Ihara Y, Monomeric C-mannosyl tryptophan is a degradation product of autophagy in cultured cells. Glycoconj J. 37, 635-645, 2020.

Ohgita T, Takechi-Haraya Y, Okada K, Matsui S, Takeuchi M, Saito C, Nishitsuji K, Uchimura K, Kawano R, Hasegawa K, Sakai-Kato K, Akaji K, Izutsu KI, Saito H, Enhancement of direct membrane penetration of arginine-rich peptides by polyproline II helix structure. Biochim Biophys Acta Biomembr., 1862, 183403, 2020.

Inai Y, Ueda K, Matsui IL, Tajiri M, Minakata S, Wada Y, Ihara Y, Role of C-mannosylation in the secretion of mindin. Biochim Biophys Acta Gen Subj., 1864, 129632, 2020.

Ikezaki M, Nishioka N, Nishikawa T, Higashimoto N, Ihara Y. Hsc70 is required for E-cadherin expression in epithelial-like NRK-52E cells. Biochem Biophys Res Commun., 527, 481-488, 2020.

Ihara Y, Ikezaki M, Takatani M, Ito Y, Calnexin/Calreticulin and Assays Related to N-Glycoprotein Folding In Vitro. Methods Mol Biol., 2132, 295-308, 2020.

Ikezaki M, Minakata S, Nishitsuji K, Tabata S, Lee Matsui IS, Takatani M, Usukura J, Ito Y, Ihara Y, Calreticulin protects insulin against reductive stress in vitro and in MIN6 cells. Biochimie., 171-172, 1-11, 2020.

Iwahashi N, Inai Y, Minakata S, Sakurai S, Manabe S, Ito Y, Ino K, Ihara Y, C-Mannosyl tryptophan increases in the plasma of patients with ovarian cancer. Oncol Lett., 19, 908-916, 2020.

Fujimoto M, Matsuzaki I, Nishitsuji K, Yamamoto Y, Murakami D, Yoshikawa T, Fukui A, Mori Y, Nishino M, Takahashi Y, Iwahashi Y, Warigaya K, Kojima F, Jinnin M, Murata SI, Adipophilin expression in cutaneous malignant melanoma is associated with high proliferation and poor clinical prognosis. Lab Invest., 100, 727-737, 2020.

Kurimitsu N, Mizuguchi C, Fujita K, Taguchi S, Ohgita T, Nishitsuji K, Shimanouchi T, Saito H, Phosphatidylethanolamine accelerates aggregation of the amyloidogenic N-terminal fragment of apoA-I. FEBS Lett., 594, 1443-1452, 2020.

2019

Sakurai S, Inai Y, Minakata S, Manabe S, Ito Y, Ihara Y, A novel assay for detection and quantification of C-mannosyl tryptophan in normal or diabetic mice. Sci Rep., 9, 4675, 2019.

Iwahashi N, Ikezaki M, Matsuzaki I, Yamamoto M, Toujima S, Murata SI, Ihara Y, Ino K, Calreticulin regulates syncytialization through control of the synthesis and transportation of E-cadherin in BeWo cells. Endocrinology., 160, 359-374, 2019.

Kameyama H, Uchimura K, Yamashita T, Kuwabara K, Mizuguchi M, Hung SC, Okuhira K, Masuda T, Kosugi T, Ohgita T, Saito H, Ando Y, Nishitsuji K, The Accumulation of Heparan Sulfate S-Domains in Kidney Transthyretin Deposits Accelerates Fibril Formation and Promotes Cytotoxicity. Am J Pathol., 189, 308-319, 2019.

Ohgita T, Takechi-Haraya Y, Nadai R, Kotani M, Tamura Y, Nishikiori K, Nishitsuji K, Uchimura K, Hasegawa K, Sakai-Kato K, Akaji K, Saito H, A novel amphipathic cell-penetrating peptide based on the N-terminal glycosaminoglycan binding region of human apolipoprotein E. Biochim Biophys Acta Biomembr., 1861, 541-549, 2019.

Mizuguchi C, Nakagawa M, Namba N, Sakai M, Kurimitsu N, Suzuki A, Fujita K, Horiuchi S, Baba T, Ohgita T, Nishitsuji K, Saito H, Mechanisms of aggregation and fibril formation of the amyloidogenic N-terminal fragment of apolipoprotein A-I. J Biol Chem., 294, 13515-13524, 2019.

2018

Nishitsuji K, Watanabe S, Xiao J, Nagatomo R, Ogawa H, Tsunematsu T, Umemoto H, Morimoto Y, Akatsu H, Inoue K, Tsuneyama K, Effect of coffee or coffee components on gut microbiome and short-chain fatty acids in a mouse model of metabolic syndrome. Sci Rep., 8, 16173, 2018.

Nishitsuji K, Heparan sulfate S-domains and extracellular sulfatases (Sulfs): their possible roles in protein aggregation diseases. Glycoconj J., 35, 387-396, 2018.

2017

Yamamoto M, Ikezaki M, Toujima S, Iwahashi N, Mizoguchi M, Nanjo S, Minami S, Ihara Y, Ino K, Calreticulin Is Involved in Invasion of Human Extravillous Trophoblasts Through Functional Regulation of Integrinβ1.  Endocrinology., 158, 3874-3889, 2017.

2016

Ikezaki M, Higashimoto N, Matsumura K, Ihara Y, Hsc70 facilitates TGF-β-induced activation of Smad2/3 in fibroblastic NRK-49F cells.  Biochem. Biophys. Res. Commun., 477, 448-453, 2016.

2015

Ihara Y, Inai Y, Ikezaki M, Matsui I.-L, Manabe S, and Ito Y, C-Mannosylation: a modification on tryptophan in cellular proteins.  In “Glycoscience: Biology and Medicine” (Eds.) Taniguchi N., Endo T., Hart G.W., Seeberger P., and Wong C.-H., Springer-Verlag GmbH, Heidelberg, Germany, 1091-1099, 2015.

2013

Prakoura N., Politis PK., Ihara Y., Michalak M., Aristidis S., Charonis AS.: Epithelial calreticulin up-regulation promotes profibrotic responses and tubulointerstitial fibrosis development. Am. J. Pathol, 183, 1474-1487, 2013.

2012

Takahashi M., Miyata S., Fujii J,. Inai Y., Ueyama S., Araki M., Soga T., Fujinawa R., Nishitani C., Ariki S., Shimizu T., Abe T., Ihara Y., Nishikimi M., Kozutsumi Y., Taniguchi N., Kuroki Y.: In vivo role of aldehyde reductase. Biochim. Biophys. Acta, 1820, 1787-1796, 2012.

Inadomi C., Murata H., Ihara Y., Goto S., Urata Y., Yodoi J., Kondo T., Sumikawa K.: Overexpression of glutaredoxin protects cardiomyocytes against nitric oxide-induced apoptpsis with suppressing the S-nitrosylation of proteins and nuclear translocation of GAPDH.
Biochem. Biophys. Res. Commun., 425, 656-661, 2012.

2011

Ihara Y., Inai Y., and Ikezaki M.: Alteration of integrin-dependent adhesion and signaling in EMT-like MDCK cells established through overexpression of calreticulin. J Cell Biochem., 112, 2518–2528, 2011.

Shiraishi N., Inai Y., Hirano Y., and Ihara Y.: Calreticulin inhibits prion protein PrP-(23-98) aggregation in vitro. Biosci. Biotechnol. Biochem., 75, 1625-1627, 2011.

Ihara Y., Inai Y., and Ikezaki M.: Protein C-mannosylation and its prospective functions in the cell. Trends Glycosci. Glycotechnol., 23, 1-13, 2011.

2010

Ihara Y., Manabe S., Ikezaki M., Inai Y., In-Sook Lee Matsui., Ohta Y, Muroi E., and Ito Y.: C-Mannosylated peptides derived from the thrombospondin type 1 repeat interact with Hsc70 to modulate its signaling in RAW264.7 cells. Glycobiology, 20, 1298-1310, 2010.

2009

Chularojmontri L., Ihara Y., Muroi E., Goto S., Kondo T., and Wattanapitayakul S.: Cytoprotective role of Phyllanthus urinaria L. and glutathione-S transferase Pi in doxorubicin-induced toxicity in H9c2 cells. J. Med. Assoc. Thai., 92, Suppl 3:S43-51, 2009.

Goto S., Kawakatsu M., Izumi S.I., Urata Y., Kageyama K., Ihara Y., Koji T., and Kondo T.: Glutathione S-transferase pi localizes in mitochondria and protects against oxidative stress. Free Radic. Biol. Med., 46, 1392-403, 2009.

Totani K., Ihara Y., Matsuo I., Tsujimoto T., and Ito Y.: The recognition motif of the glycoprotein-folding sensor enzyme, UDP-glc: glycoprotein glucosyltransferase. Biochemistry, 48, 2933-2940, 2009.

Shiraishi, N., Inai Y., and Ihara Y.: Proteinase K-resistant aggregates of recombinant prion protein PrP-(23-98) are toxic to cultured cells. Protein Peptide Lett., 16, 91-96, 2009.

2008

Totani K., Ihara Y., Matsuo I., and Ito Y.: Effects of macromolecular crowding on glycoprotein processing enzymes. J. Am. Chem. Soc., 130, 2101-2107, 2008.

Ihara Y.: Calreticulin. In "Encyclopedia of Cancer, 2nd Edition" (Ed) Schwab M, Springer-Verlag GmbH, Heidelberg, Germany, pp. 456-459, 2008

2007

Muroi E., Manabe S., Ikezaki M., Urata Y., Sato S., Kondo T., Ito Y., and Ihara Y.: C-Mannosylated peptides derived from the thrombospondin type 1 repeat enhance lipopolysaccharide-induced signaling in macrophage-like RAW264.7 cells. Glycobiology, 17, 1015-1028, 2007.

Nonaka K., Kume N., Urata Y., Seto S., Kono T., Honda S., Ikeda S., Muroya T., Ikeda Y., Ihara Y., Kita T., and Kondo T.: Serum levels of S-glutathionylated proteins is a risk-marker for arteriosclerosis obliterans. Circulation J., 71, 100-105, 2007.

Ito Y., Ihara Y., and Manabe S.: C-Mannosyl tryptophan (CMW): from chemistry to cell biology. In "Comprehensive Glycoscience, from Chemistry to Systems Biology" (Kamerling J.P., ed.), pp 229-248, Elsevier, Oxford, UK, 2007

2006

Shiraishi N., Utsunomiya H., and Nishikimi M.: Combination of NADPH and copper ions generates proteinase K-resistant aggregates from recombinant prion protein. J. Biol. Chem., 281, 34880-34887, 2006.

Kondo Y., Inai Y., Sato Y., Handa S., Kubo S., Shimokado K., Goto S., Nishikimi M., Maruyama N., and Ishigami A.: Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy. Proc. Natl. Acad. Sci. U.S.A., 103, 5723-5728, 2006.

Hayashida Y., Urata Y., Muroi E., Kono T., Miyata Y., Nomata K., Kanetake H., Kondo T., and Ihara Y.: Calreticulin represses E-cadherin gene expression in MDCK cells via slug. J. Biol. Chem., 281, 32469-32484, 2006.

Totani K., Ihara Y., Matsuo I., and Ito Y.: Substrate specificity analysis of endoplasmic reticulum glucosidase II using synthetic high-mannose-type glycans. J. Biol. Chem., 281, 31502-31508, 2006.

Kanda M., Ihara Y., Murata H., Urata Y., Kono T., Yodoi J., Seto S., Yano K., and Kondo T.: Glutaredoxin modulates PDGF-dependent cell signaling by regulating the redox status of low molecular weight protein tyrosine phosphatase. J. Biol. Chem., 281, 28518-28528, 2006.

Okunaga T., Urata Y., Goto S., Matsuo T., Mizota S., Tsutsumi K., Nagata I., Kondo T., and Ihara Y.: Calreticulin, a molecular chaperone in the endoplasmic reticulum, modulates radiosensitivity of human glioblastoma U251MG cells. Cancer Res., 66, 8662-8671, 2006.

Totani K., Matsuo I., Ihara Y., and Ito Y.: High-mannose-type glycan modifications of dehydrofolate reductase using glycan-methotrexate conjugates. Bioorg. Med. Chem., 14, 5220-5229, 2006.

Urata Y., Ihara Y., Murata H., Goto S., Koji T., Yodoi J., Inoue S., and Kondo T.: 17-beta-estradiol protects against oxidative stress-induced cell death through the glutathione/glutaredoxin-dependent redox regulation of Akt in myocardiac H9c2 cells. J. Biol. Chem., 281, 13092-13102, 2006.

Ihara Y., Urata Y., Goto S., and Kondo T.: Role of calreticulin in the sensitivity of myocardiac H9c2 cells to oxidative stress caused by hydrogen peroxide. Am. J. Physiol. Cell Physiol., 290, C208-221, 2006.

2005

Inai Y., Bi W., Shiraishi N., and Nishikimi M.: Enhanced oxidative stress by L-ascorbic acid within cells challenged by hydrogen peroxide. J. Nutr. Sci. Vitaminol. (Tokyo)., 51, 398-405, 2005.

Shiraishi N., Inai Y., Bi W., and Nishikimi M.: Fragmentation and dimerization of copper-loaded prion protein by copper-catalysed oxidation. Biochem. J., 387, 247-255, 2005.

Bi W., Inai Y., Shiraishi N., Maeta K., Takatsume Y., Inoue Y., Nishikimi M.: Cytosolic protein as principal copper buffer in an early response to copper by yeast cells. J. Clin. Biochem. Nutr. 36, 19-27, 2005.

Kamiya Y., Yamaguchi Y., Takahashi N., Arata Y., Kasai K.-I., Ihara Y., Matsuo I., Ito Y., Yamamoto K., and Kato K.: Sugar-binding properties of VIP36, an intracellular animal lectin operating as a cargo receptor. J. Biol. Chem., 280, 37178-37182, 2005.

Totani K., Ihara Y., Matsuo I., Koshino H., and Ito Y.: Synthetic substrates for ER protein folding sensor, UDP-glucose: glycoprotein glucosyltransferase. Angew. Chem. Int. Ed., 44, 7950-7954, 2005.

Ihara Y., Kageyama K., and Kondo T.: Overexpression of calreticulin sensitizes SERCA2a to oxidative stress. Biochem. Biopys. Res. Commun., 329, 1343-1349, 2005.

Ihara Y., Manabe S., Kanda M., Kawano H., Nakayama T., Sekine I., Kondo T., and Ito Y.: Increased expression of protein C-mannosylation in the aortic vessels of diabetic Zucker rats. Glycobiology, 15, 383-392, 2005.

[日本語総説など]

2024

西辻和親、内村健治：「硫酸化修飾が制御するコンホメーション病におけるグリコサミノグリカンの病態機能」、生化学、96巻2号、p143‒151 (2024)

2021

西辻　和親、内村　健治：「アミロイドーシス病態における硫酸化グリコサミノグリカン糖鎖の役割」、Trends in Glycoscience and Glycotechnology、33巻196号, J141–J145 (2021)

2019

常山幸一、市村真祐子、尾矢剛志、松本穣、小林智子、小川博久、西辻和親、山下理子：「肝臓病理所見のとり方とその解釈」、法医病理 25巻1号, p1–12 (2019)

2018

井原義人: Ⅲ．細胞膜での分子修飾 膜タンパク質 「C-マンノシル化」、増大特集 タンパク質・核酸の分子修飾、生体の科学、医学書院、69巻5号、p500-501 (2018)
西辻和親、内村健治：「アミロイドβの蓄積に関わる構造糖鎖の発見」アルツハイマー病　発症メカニズムと新規診断法・創薬・治療開発（監修：新井平伊）、エヌ・ティー・エス、p. 55–64 (2018)

2011

眞鍋史乃、井原義人、伊藤幸成：化学の窓「新規タンパク質マンノシル付加修飾：合成化学からの生物学への貢献」、化学と生物 49巻 5号、p347-351 (2011)

2010

井原義人、池﨑みどり:「酸化ストレスおよびERストレス」 糖尿病性細小血管症(第2版)-発症・進展制御の最前線-、日本臨牀 68巻 増刊号9、p49-52 (2010)

2009

井原義人:「ERと酸化ストレス、病態解明に迫る 活性酸素シグナルと酸化ストレス」 癌、神経変性疾患、循環・代謝異常にかかわるレドックス制御機構と最新の技術開発(谷口直之 監、赤池孝章、鈴木敬一郎、内田浩二 編)、実験医学 増刊、羊土社、p92-96 (2009)

古澤元, 佐藤安訓, 田中康一, 井内陽子, 天野晶, 岩間水輝, 近藤嘉高, 半田節子, 村田晃, 錦見盛光, 後藤佐多良, 丸山直記, 高橋良哉, 石神昭人:「カルニチン合成系へのビタミンCの関与」Vitamins (Japan) 83 (5" 6)、p287-289 (2009)

2008

井原義人：「分泌・膜タンパク質の折りたたみ制御と病気」　和歌山医学　59巻1号、p2-8 (2008)

2007

錦見盛光：「壊血病発症動物における遺伝子異常の解析」　ビタミン81巻1号、p1-8 (2007)

2006

井内陽子、錦見盛光：「グルコノラクトナーゼ欠損による壊血病発症」　ビタミン80巻10号、p519-520 (2006)

2005

井原義人：「分子シャペロンによる糖鎖を介したタンパク質の品質管理機構」　糖鎖科学の新展開　-機能解明・次世代材料・医薬品開発に向けて-（谷口直之、伊藤幸成　編）、エヌ・ティー・エス、p92-98 (2005) 井原義人：「糖鎖を介した糖タンパク質の品質管理とシャペロン分子機構」　糖鎖と病気（谷口直之　編）、遺伝子医学MOOK　3号、メディカルドゥ、p111-117 (2005) 近藤宇史、井原義人：「グルタチオンシステム」　レドックス - ストレス防御の医学「別冊・医学のあゆみ」、医歯薬出版、p14-18 (2005)