遺伝子制御学研究部

教室概要

器官形成過程のエッセンスを知りたい；泌尿生殖系器官形成メカニズム解析を通じ器官形成プログラムに迫る

我々は遺伝子改変マウス（コンディショナルミュータントマウス等）を駆使し、器官形成の根幹的な発生プログラムを明らかにしたいと考えています。器官形成プログラムは近年種々器官での解析が進み、その制御カスケード（細胞増殖因子群等を含む）はある程度器官形成の間で保存されている事も明らかとなってきました。例えば、体幹部から伸びる四肢形成や頭部、体幹形成等発生プログラムにおいては転写制御因子群や細胞増殖因子群がうまく組み込まれていますが、それら制御カスケードの流れにはある程度保存性があることが分かってきたのです。

泌尿生殖系器官は我々、哺乳類にとって最も重要な器官系のひとつです。その器官発生メカニズム解明は上記の一般器官発生プログラム解明に比べて大きく遅れてきました。それでは、雄や雌に最終的に分化すべき泌尿生殖系器官の発生プログラムは一般発生プログラムと比較してどのように類似し、かつダイバージして（相違して）構成されているのでしょうか。またこの分野に関連して大きな研究の進展が期待される分野があります。それは性差の形成という研究領域です。性差の形成は生殖器官の発生機構の解明と深く関わっています。同時に人の病気でも性差を呈するプロセスが数多くあります。しかしながら性差の形成そのもの、例えば器官が出来る際においてもそのプロセスにどういった制御因子群が関わっているかはこれまで本格的に解析はされていませんでした。私達は泌尿生殖器官の解明というプロジェクトに始まり今後は性差の決定に関わる因子群の働き、機能解明、そして病気の理解も含めて研究を進めて行きたいと考えております。生殖系器官は先天性発生異常や疾患が多くおこる部位です。先天性発生異常としては尿道異常などが有名で、この尿道異常に関与する遺伝子を細胞増殖因子系で世界で初めて示唆しました。これらの中にはヘッジホッグという増殖因子も含まれ　興味あることに前立腺癌などにその関与が疑われていました。また生殖系器官群では上皮系発生が器官として重要ですが、この生殖系器官の上皮の特徴づけを行うシグナル系としても、Ｗｎｔシグナル関与を示す興味深い知見が得られています。このＷｎｔシグナル等は他の器官系上皮、たとえば皮膚発生にて異物から体を守る、いわばバリア機能を可能にするため重要です。一方異物である受精卵を”受容する”子宮内膜など、異なる性質を持つ上皮形成にも同じ因子がかかわっているのかという興味深い問いがあります。このように我々のラボではこうした研究を世界に先駆けて根本的な知見を得るべく日夜努力しております。 またラボ見学ご希望の方はご連絡ください。海外留学生非常に多く有する国際色あるラボです。

（ラボセミナ言語はここ約12年間、英語です。教授への悪口も英語）多くの若い学生さんがいます。
国際的ラボで御自身をみがいて下さい。

• アンドロロジー学会を開催致しました。

大まかなプロジェクトの概要（国際的視野を有する発生医学教育、研究）

1. 泌尿生殖器官系の発生メカニズムを遺伝子ノックアウトマウス、コンディショナルノックアウトマウスを用いて解明する
2. 性差の形成、発現メカニズムの根幹を器官形成プロセスにおいて解明する。
3. 四肢や外部生殖器の発生メカニズムを分子的に比較解明する。その類似性、相違性について解析する。
4. 泌尿生殖器官系は”統合して”形成される。その協調発生メカニズムを解明する；発生異常はいくつかカップルし発生異常症候群として現れるが　その原因を解明する。
5. 上皮系形成は組織分化として器官形成の中で重要なイベントである。生殖器官系は特有の上皮形成、及び分化メカニズムを有している。生殖器官系上皮がそのユニークな性質を獲得するための　発生プログラムを解明する。それら発生プログラムが他の器官系、例えば皮膚等の発生プログラムと比較していかなる類似性、相違性があるのか解明する。

スタッフ紹介

教授	山田　源	Genyama77(@)yahoo.co.jp transg8(@)wakayama-med.ac.jp
講師	鈴木　堅太郎 宮川　信一	k-suzuki(@)wakayama-med.ac.jp miyagawa(@)wakayama-med.ac.jp
研究員	Lerrie ann Ipulan 松丸　大輔 村嶋　亜紀 谷津　遼平 松下　祥子
博士、 修士大学院生 （博士）	梶岡　大暉 Alvin Acebedo 長谷川　翔 平野　優
大学院生 （修士）	崎田　佳嗣 橋本　大輝　　 田上　健太  Jose G Colet 梶本　みずき 佐伯　英俊

近年業績について Researchgate gen yamadaでも検索ください。

研究業績

• Suzuki H, Matsushita S, Suzuki K and Yamada G.
  5α-Dihydrotestosterone negatively regulates cell proliferation of the periurethral ventral mesenchyme during urethral tube formation in the murine male genital tubercle.
  Andrology. 2016 in press
• Matsushita S, Suzuki K, Ogino Y, Hino S, Sato T, Suyama M, Matsumoto T, Omori A, Inoue S, Yamada G.
  Androgen Regulates Mafb Expression Through its 3'UTR During Mouse Urethral Masculinization.
  Endocrinology. 2016 Feb;157(2):844-57. doi:
  10.1210/en.2015-1586. Epub 2015 Dec 4.
• Matsumaru D, Murashima A, Fukushima J, Senda S, Matsushita S, Nakagata N, Miyajima M, Yamada G.
  Systematic stereoscopic analyses for cloacal development: The origin of anorectal malformations.
  Sci Rep. 2015 Sep 10;5:13943. doi: 10.1038/srep13943.
• Okazawa M, Murashima A, Harada M, Nakagata N, Noguchi M, Morimoto M, Kimura T, Ornitz DM,Yamada G.
  Region-specific regulation of cell proliferation by FGF receptor signaling during the Wolffian duct development.
  Dev Biol. 2015 Apr 1;400(1):139-47. doi:
  10.1016/j.ydbio.2015.01.023. Epub 2015 Feb 9.
• Harada H, Omori A, Nakahara C, Nakagata N, Akita K and Yamada, G.
  Tissue-specific roles of FGF signaling in external genitalia development
  Dev Dyn , 2015
  
• Ipulan LA, Suzuki K, Sakamoto
  Y, Murashima A, Imai Y, Omori A, Nakagata N, Nishinakamura R, Valasek P and Yamada G.
  Non-myocytic androgen receptor regulates the sexually dimorphic
  development of the embryonic bulbocavernosus muscle.
  Endocrinology, 155(7):2467-79. doi: 10.1210/en.2014-1008. Epub 2014
• Miyagawa S, Sato M, SudoT, Yamada G and Iguchi T.
  Unique Roles of Estrogen-Dependent Pten Control in Epithelial Cell
  Homeostasis of Mouse Vagina.
  Oncogene, 2014 Mar 17. doi: 10.1038/onc.2014.62. 2014
• Omori A, Miyagawa S, Ogino Y, Harada M, Ishii K, Sugimura Y, Ogino H,
  Nakagata N and Yamada G.
  Essential roles of epithelial bone morphogenetic protein signaling during
  prostatic development.
  Endocrinology, 2014 Jul;155(7):2534-44. 2014
• Murashima A, Kishigami S, Thomson A, Yamada G.
  Androgens and mammalian male reproductive tract development
  Biochimica et Biophysica Acta, 2014 in press, 2014
• Murashima A, Akita H, Okazawa M, Kishigami S, Nakagata N, Nishinakamura R, Yamada G.
  Midline-derived Shh regulates mesonephric tubule formation through the
  paraxial mesoderm
  Developmental Biology, Volume 386, Issue 1 , Pages 216 226 2014
• SuzukiK, NumataT, Suzuki H, RagaDD, Ipulana L, YokoyamaC,
  MatsushitaS, HamadaM, NakagataN,NishinakamuraR, KumeS, TakahashiS, and Yamada G.
  Sexually dimorphic expression of Mafb regulates masculinization of the embryonic urethral formation
  PNAS, 111(46):16407-12. doi: 10.1073/pnas.1413273111. Epub 2014
• Ipulan LA, Suzuki K, Matsushita S, Suzuki H, Okazawa M, Jacinto S, Hirai S and Yamada G.
  Development of the External Genitalia and its Sexual Dimorphic Regulation.
  Sexual Development, 8(5):297-310. 2014
• Miyagawa S, Harada M, Matsumaru D, Tanaka K, Inoue C, Nakahara C, Haraguchi R, Matsushita S, Suzuki K, Nakagata N, Ng RC, Akita K, Lui VC and Yamada G.
  Disruption of the Temporally Regulated Cloaca Endodermal β-catenin Signaling Causes Anorectal Malformations.
  Cell Death Differentiation, 21, 990-997 2014
• Ng RC, Matsumaru D, Ho A, Garcia-Barcelo MM, Yuan ZW, Smith D, Kodjabachian L, Tam P, Yamada G and Lui VC.
  Dysregulation of Wnt Inhibitory Factor 1 (Wif1) expression resulted in aberrant Wnt-β-catenin signaling and cell death of the cloaca endoderm, and anorectal malformations.
  Cell Death Differentiation, 21,978-989 2014
• Murashima A, Akita H, Okazawa M, Kishigami S, Nakagata N, Nishinakamura R and Yamada G.
  Midline-derived Shh regulates mesonephric tubule formation through the paraxial mesoderm.
  Dev Biol, 386, 216-226,2014
• L Ann Ipulan, Suzuki K, Matsushita S, Suzuki H, Okazawa M, Jacinto S, Hirai S and Yamada G.
  Development of the External Genitalia and its Sexual Dimorphic Regulation.
  Sexual Development, 2013 (in press)
• Ogino Y, Hirakawa I, Inohaya K, Sumiya E, Yamada G and Iguchi T.
  Bmp7 and Lef1 are the downstream effectors of androgen signaling in androgen-induced sex characteristics development in medaka.
  Endocrinology, 2013 (in press)
• Matsumaru D, Haraguchi R, Anne M. Moon, Satoh Y, Nakagata N, Yamamura K, Takahashi N, Kitazawa S and Yamada G.
  Genetic analysis of the role of Alx4 in the coordination of lower body and external genitalia formation.
  Eur J Hum Genet, 2013 (in press)
• Semba K, Araki K, Matsumoto K, Suda H, Ando T, Sei A, Mizuta H, Takagi K, Nakahara M, Muta M, Yamada G, Nakagata N, Iida A, Ikegawa S, Nakamura Y, Araki M, Abe K and Yamamura K.
  Ectopic Expression of Ptf1a Induces Spinal Defects, Urogenital Defects, and Anorectal Malformations in Danforth's Short Tail Mice
  PLoS Genet, 9, e1003204. doi:10.1371/journal.pgen.1003204, 2013
• *Villacorte M, *Suzuki K, Hirasawa A, Ohkawa Y, Suyama M, Maruyama T, Aoki D, Ogino Y, Miyagawa S, Terabayashi T, Tomooka Y, Nakagata N and Yamada G.
  Beta-catenin signaling regulates Foxa2 expression during endometrial hyperplasia formation.
  Oncogene, 32, 3477-3482, 2013
  (*equaly contributed first author)
• Suzuki K, Adachi Y, Numata T, Nakada S, Yanagita M, Nakagata N, Evans M.S., Graf D, Economides A, Haraguchi R, Moon M.A. and Yamada G.
  Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: a new mouse model of sirenomelia.
  PLoS ONE, 7(9):e43453. doi: 10.1371/journal.pone.0043453, 2012
• *Haraguchi R, *Matsumaru D, Nakagata N, Miyagawa S, Suzuki K, Kitazawa S and Yamada G.
  The Hedgehog Signal Induced Modulation of Bone Morphogenetic Protein Signaling: An Essential Signaling Relay for Urinary Tract Morphogenesis.
  PLoS ONE, 7(7):e42245. doi: 10.1371/journal.pone.0042245, 2012
  (*equaly contributed first author)
• Yamaguchi M, Ohba T, Tashiro H, Yamada G and Katabuchi H.
  Human chorionic gonadotropin induces human macrophages to form intracytoplasmic vacuoles mimicking Hofbauer cells in human chorionic villi.
  CELLS TISSUES ORGANS, 2012 (in press)
• Mazahery A, Suzuki K, Nagafuchi A, Miyajima M, Nakagata N, Behringer R and *Yamada G.
  Functional analysis of ectodermal β-catenin during external genitalia formation.
  Congenital Anomalies, 2012 (in press)
• Okano J, Kimura W, Virginia E. Papaionnou, Miura N, Yamada G, Shiota K and Sakai Y.
  The Regulation of Endogenous Retinoic Acid Level Through CYP26B1 Is Required for Elevation of Palatal Shelves.
  DEV DYN 241, 1744-1756, 2012
• Ohta S, Yukiko O, Suzuki K, Kamimura M, Tachibana K and Yamada G.
  Sonoporation for gene transfer into embryos.
  Cold Spring Harb Protoc., 3, prot5581, 2011
• Essential functions of androgen signaling emerged through the developmental analysis of vertebrate sex characteristics.
  Ogino Y, Miyagawa S, Katoh H, Prins GS, Iguchi T, Yamada G.
  Evol Dev. 2011 ;13(3):315-25
• Liu,L., Suzuki,K., Nakagata,N., Mihara,K., Matsumaru,D., Ogino,Y., Yashiro,Y., Hamada,H., Liu,X., Evans,S., Mendelsohn,C. and Yamada,G. : Retinoic acid signaling regulates Sonic hedgehog and Bone morphogenetic protein signalings during genital tubercle development. : Birth Defects Res B Dev Reprod Toxicol., 2011, in press , 2011 . doi: 10.1002/bdrb.20344.
• Omori,A., Harada,M., Ohta,S., Villacorte,M., Sugimura,Y., Shiraishi,T., Suzuki,K., Nakagata,N., Ito,T. and Yamada,G. : Epithelial Bmp (Bone morphogenetic protein) signaling for bulbourethral gland development : A mouse model for congenital cystic dilation. Congenit Anom,　51:102-109, 2011
• Miyagawa,S., Matsumaru,D., Murashima,A., Omori,A., Satoh,Y., Haraguchi,R., Motoyama,J., Iguchi,T., Nakagata,N., Chi-chung Hui and Yamada,G. : The role of Sonic hedgehog-Gli2 pathway in the masculinization of external genitalia. : Endocrinology, 152:2894-903, 2011
• Genetic analysis of Hedgehog signaling in ventral body wall development and the onset of omphalocele formation.
  Matsumaru D, Haraguchi R, Miyagawa S, Motoyama J, Nakagata N, Meijlink F, Yamada G. PLoS One. 2011 20;6(1):e16260.
  
• Ohta,S., Yukiko,O., Suzuki,K., Kamimura,M., Tachibana,K. and Yamada,G. Sonoporation for gene transfer into embryos. Cold Spring Harb Protoc. 2011 Mar 1
• Murashima,A., Miyagawa,S., Ogino,Y., Nishida-Fukuda,H., Araki,K., Matsumoto,T., Kaneko,T., Yoshinaga,K., Yamamura,KI., Kurita,T., Kato,S., Moon,AM. and Yamada,G. Essential Roles of Androgen Signaling in Wolffian Duct Stabilization and Epididymal Cell Differentiation. Endocrinology. 152(4):1640-51, 2011 (Faculty of 1000 Medicine )
  http://f1000.com/9011956
• Kim-Kaneyama,JR., Takeda,N,. Sasai,A., Miyazaki,A., Sata,M., Hirabayashi,T., Shibanuma,M., Yamada,G and Nose,K. Hic-5 deficiency enhances mechanosensitive apoptosis and modulates vascular remodeling. J Mol Cell Cardiol., 50(1):77-86, 2011.
• 鈴木堅太郎、山田源．　外生殖器の発生分化と異常のモデル．　完全版マウス・ラット疾患モデル活用ハンドブック 394-408、2011
• Villacorte,M., Suzuki,K., Hayashi,K., Chuva de Sousa-Lopes,S., Haraguchi,R., Taketo,M.M., Nakagata,N. and Yamada,G. Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling within the Apical Ectodermal Ridge (AER) regulates interdigit formation. Biochem Biophys Res Commun. 391:1653-1657, 2010
• Imamura,Y., Ishikawa,S., Sato,N., Karashima,R., Hiyoshi,Y., Nagai,Y., Koga,Y., Hayashi,N., Watanabe,M., Yamada,G. and Baba,H. Adenoviral oncolytic suicide gene therapy for a peritoneal dissemination model of gastric cancer in mice. Ann Surg Oncol., 17:643-652,2010
• Fukami,M., Nagai,T., Mochizuki,H., Muroya,K., Yamada,G., Takitani,K. and Ogata,T. Anorectal and urinary anomalies and aberrant retinoic acid metabolism in cytochrome P450 oxidoreductase deficiency. Mol Genet Metab., 100:269-273,2010
• Ohta,S., Schoenwolf GC and Yamada,G. Thecessation of gastrulation BMP signaling and EMT during and at the end of gastrulation. Cell Adh Migr., 4:3,1-7;2010
• 原田理代、山田源. 外生殖器・内生殖器 発生過程におけるWntシグナルの役割．　医学の歩み vol.233 number10(1008-1014), 2010
• 宮川信一、原田理代、原口竜摩、鈴木堅太郎、中原千彰、松丸大輔、金子武人中潟直己、山田 源．Hedgehog，Wnt，FGFの三大増殖因子の相互作用：器官が伸長する（大きくなる）ためにどのようなリレーが必要か．細胞工学　Vol.29 No.2(188-189), 2010
• Miyagawa,S.,, Moon,A., Haraguchi,R., Inoue,C., Harada,M., Nakahara,C., Suzuki,K., Matsumaru.D., Kaneko,T., Matsuo,I., Yang,L., Taketo,M.M., Iguchi,T., Evans,S.M and Yamada,G. Dosage dependent hedgehog signals integrated with 1 Wnt/β-catenin regulate embryonic external genitalia formation as an appendicular program. Development, 136: 3969-3978, 2009
• Suzuki,K., Yamaguchi,Y., Villacorte,M., Mihara,M., Akiyama,M., Shimizu,H., Taketo,M.M., Nakagata,N., Tsukiyama,T., Yamaguchi,T.P., Birchmeier,W., Kato,S. and Yamada,G. Embryonic hair follicle fate change by augmented β-catenin through Shh and Bmp signaling. Development, 136:367-372, 2009.
  Faculty of 1000 Medicine "Must Read"
• Ogino,Y., Katoh,H., Kuraku,S. and Yamada,G. Evolutionary history and functional characterization of androgen receptor genes in jawed vertebrates. Endocrinology, 150:5415-5427, 2009
• Miyagawa,S., Satoh,Y., Haraguchi,R., Suzuki,K., Iguchi,T., Taketo,M.M., Nakagata,N., Matsumoto,T., Takeyama,KI., Kato,S. and and Yamada,G. Genetic interactions of the Androgen and Wnt/β-catenin Pathways for the Masculinization of External Genitalia. Mol.Endocrinol., 23:871-80, 2009
• Suzuki.K., Economides,A., Yanagita,M., Graf,D. and Yamada,G. New horizons at the caudal embryos: coordinated urogenital/ reproductive organ formation by growth factor signaling. Curr Opin Genet Dev., 19:491-6, 2009
• Aoto,K., Shikata,Y., Imai,H., Matsumaru,D., Tokunaga,T., Shioda,S., Yamada,G. and Motoyama,J. Mouse Shh is required for prechordal plate maintenance during brain and craniofacial Morphogenesis. Dev Biol., 327:106-20, 2009
• 鈴木堅太郎、山口裕史、ヴィラコルテマイラ、秋山真志、清水宏、中潟直己、山田源. 皮膚バイオロジーから見えてきた増殖因子シグナルクロストークによる細胞系譜制御；皮膚発生から生殖系発生メカニズムの解明に向けて. 細胞工学 2009年3月号272-3頁
• Nishida,H., Miyagawa,S., Vieux-Rochas,M., Morini,M., Ogino,Y., Suzuki,K., Nakagata,N., Choi,HS., Levi,G. and Yamada,G. Positive regulation of steroidogenic acute regulatory protein (StAR) gene expression through the interaction between Dlx and GATA-4 for testicular steroidogenesis. Endocrinology, 149:2090-7, 2008
• Suzuki,K., Haraguchi,R., Ogata,T., Barbieri,O., Alegria,O., Vieux-Rochas,M., Nakagata,N., Ito,M., Mills,A., Kurita,T., Levi,G. and Yamada,G. Abnormal urethra formation in mouse models of Split-hand/split-foot malformation type 1 and type 4. Eur J Hum Genet., 16:36-44, 2008
• *Nishida,H., *Miyagawa,S., Matsumaru,D., Wada,Y., Satoh,Y., Ogino,Y., Fukuda,S., Iguchi,T. and Yamada,G. Gene expression analyses on the embryonic external genitalia:identification of regulatory genes possibly involved in masculinization processes. Congenit Anom (Kyoto), 48:63-7, 2008. *equaly contributed first author
• Ohta,S., Suzuki,K., Ogino,Y., Miyagawa,S., Murashima,A., Matsumaru,D. and Yamada,G. Gene transduction by Sonoporation. Dev Growth Differ., 50:517-20, 2008
• Ohta,S., Suzuki,K., Kamimura,M., Norikoshi,Y., Zhang,Y., Nakagata,N., Tachibana,K. and Yamada,G. Efficient Gene Transduction Technique by Microbubble-Enhanced Sonoporation for embryology. in "Molecular Embryology: Methods and Protocols (Methods in Molecular Biology)" edited by Sharpe,P. Humana Press. Totowa, New jersey, 2008
• He,F., Xiong,W., Yu,X., Espinoza-Lewis,R., Liu,C., Gu,S., Nishita,M., Suzuki,K., Yamada,G., Minami,Y. and Chen,YP. Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development. Development. 135:3871-9, 2008.
• Inagaki,M., Omori,E., Kim, JY., Komatsu,Y., Scott,G., Ray,M.K., Yamada,G., Matsumoto,M., Mishina,Y. and Ninomiya-TsujiJ. TAK1 binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling. J Biol Chem. 283:33080-6, 2008.
• Ohnishi,N., Yuasa,H., Tanaka,S., Sawa,H., Miura,M., Matsui,A., Higashi,H., Musashi,M., Iwabuchi,K., Suzuki,M., Yamada,G., Azuma,T. and Hatakeyama,M. Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Proc Natl Acad Sci USA., 105:1003-8, 2008
• Inagaki,M., Komatsu,Y., Scott,G., Yamada,G., Ray,M., Ninomiya-Tsuji,J and Mishina,Y. Generation of a conditional mutant allele for Tab1 in mouse. Genesis, 46:431-9, 2008
• Wada,Y., Takahashi,W., Latifpour,J., Weiss,R.M., Matsumoto,K., Matsui,K., Yamada,G. and Imamura,T. Prostate expression of endothelins and their receptors in rat growth. Reprod Fertil Dev. 20:750-9, 2008.
• EMT研究がいま面白い．　山田源　監修．　細胞工学　2008年4月号（27：4: 314-367）
• 太田 将，鈴木堅太郎，立花克郎，田中英明，山田 源．　　原腸陥入の停止とEMTの制御：外生殖器，後肢を含む後方体幹部の発生機構への理解． 細胞工学　2008年2月号（27:2,
• Ohta,S., Suzuki,K., Tachibana,K., Tanaka,H. and Yamada,G. Cessation of gastrulation is mediated by suppression of Epithelial-Mesenchymal Transition (EMT) at the Ventral ectodermal ridge. Development, 134:4315-24, 2007
• Haraguchi,R., Motoyama,J., Sasaki,H., Satoh,Y., Miyagawa,S., Nakagata,N., Moon,A. and Yamada,G. Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling. Development 134: 525-533, 2007
• Takada,I., Mihara,M, Suzawa,M., Ohtake,F., Kobayashi,S., Igarzashi,M., Youn,MY., Takeyama,KI., Nakamura,T., Mezaki,Y., Takezawa,S., Yogiashi,Y., Kitagawa,H., Yamada,G., Takada,S., Minami,Y., Shibuya,H., Matsumoto,K. and Kato,S. A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation. Nat Cell Biol., 11:1273-85, 2007
• Little,M.H., Brennan,J., Georgas,K., Davies,J.A., Davidson,D.R., Baldock,R.A., Beverdam,A., Bertram,J.F., Capel,B., Chiu,H.S., Clements,D., Cullen-McEwen,L., Fleming,J., Gilbert,T., Houghton,D., Kaufman,M.H. Kleymenova,E., Koopman,P.A., Lewis,A.G., McMahon,A.P., Mendelsohn,C.L., Mitchell,E.K., Rumballe,B.A., Sweeney,D.E., Valerius,M.T., Yamada,G., Yang,Y. and Yu,J.: A high-resolution anatomical ontology of the developing murine genitourinary tract. Gene Expr Patterns, 7: 680-99, 2007
• Wada,Y., Takahashi,W., Latifpour,J., Yamada,G., Kai,N., Honda,J., Nakanishi,J. and Weiss,RM. Regional differences in the functional and biochemical properties of endothelin receptor subtypes in the rabbit prostatic urethra. BJU Int. 100:430-7, 2007
• Miyado,M., Ogi,H., Yamada,G., Kitoh,J., Jogahara,T., Oda,S., Sato,I., Miyado,K., Sunohara,M. Sonic hedgehog expression during early tooth development in Suncus murinus. Biochem Biophys Res Commun., 363: 269-275, 2007
• 原口竜摩、佐藤義彦、宮川信一、松丸大輔、中潟直己、山田源．連携して器官を発生させる：ヘッジホッグシグナルによる骨盤内外器官群の協調発生機構、細胞工学　2007年 3月号　（26:3, 296-297）
• Yamada,G., Suzuki,K., Haraguchi,R., Miyagawa,S., Satoh,Y., Kamimura,M., Nakagata,N., Kataoka,H., Kuroiwa,A. and Chen,Y.P. Molecular genetic cascades for external genitalia formation: an emerging organogenesis program. Dev.Dyn. 235(7) 1738-1752, 2006
• Ohta,S., Ogino,Y., Suzuki,K., Kamimura,M., Tachibana,K. and Yamada,G. Sonoporation; Efficient Gene Transduction Technique for Embryos. In "DNA Deliver/Gene Transfer" edited by Friedmann,T. and Rossi,J. Cold Spring Harbor Laboratory Press. Woodbury, New York. P711-716, 2006.
• Katoh,H., Ogino,Y. and Yamada,G. Cloning and expression analysis of androgen receptor gene in chicken embryogenesis. FEBS Lett. 6;580(6):1607-15, 2006
• Fukami,M., Wada,Y., Miyabayashi,K., Nishino,I., Hasegawa,T., Camerino,G., Kretz,C., Buj-Bello,A., Laporte,J., Yamada,G., Morohashi,K. and Ogata,T. CXorf6 is a causative gene for hypospadias. Nat Genet. 38(12):1369-71. 2006
• Kumai,T., Yamada,G., Takekura,Y., Tohno,Y. and Benjamin,M. Trace Elements in Human Tendons and Ligaments. Biol Trace Elem Res. 114:151-161, 2006
• Izu,A., Kumai,T., Tohno,Y., Tohno,S., Minami,T., Yamada,G. and Yamada MI. Intake to Vertebral Columns of Mice After Dietary Supply. Biol Trace Elem Res. 113:297-316, 2006
• Suzuki,K., Nishida,H., Ohta,S., Satoh,Y., Xu,Y., Zhang,Y., Wada,Y., Ogino,Y., Nakagata,N., Ohba,T. and Yamada,G. External Genitalia Development: A Model System to Study Organogenesis. Genetically Engineered mice Handbook. Taylor & Francis Books. Boca Raton, FL., 263-278, 2005
• Shim,JH., Xiao,C., Paschal,AE., Bailey,ST., Rao,P., Hayden,MS., Lee,KY., Bussey,C., Steckel,M., Tanaka,N., Yamada,G., Akira,S., Matsumoto,K., Ghosh,S. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. 19(22):2668-81, 2005
• Yamada,G. Reproductive/urogenital organ development and the molecular genetic cascades; glamorous developmental processes of bodies. J Biochem (Tokyo). 137:665-9, 2005
• Ogi,H., Suzuki,K., Ogino,Y., Kamimura,M., Miyado,M., Ying,X., Zhang,Z., Shinohara,M., Chen,YP. and Yamada,G. The ventral abdominal wall dysmorphogenesis of Msx1/Msx2 double-mutant mice. Anat Rec. 31;284A:424-430, 2005
• Kamikawa-Miyado,M., Ogi,H., Ogino,Y., Katoh,H., Suzuki,K., Uemura,M., Kitoh,J., Oda,S. and Yamada,G. The morphological and histological characters of the male external genitalia of the house musk shrew, Suncus murinus. Zoolog Sci. 22:463-8, 2005
• Tanaka,H., Nagaike.K., Takeda,N., Itoh,H., Kohama,K., Fukushima,T., Miyata,S., Uchiyama,S., Uchinokura,S., Shimomura,T., Miyazawa,K., Kitamura,N., Yamada,G. and Kataoka,H. Hepatocyte Growth Factor Activator Inhibitor Type 1 (HAI-1) is Required for Branching Morphogenesis in the Chorioallantonic Placenta. Mol. Cell. Biol. 25:5687-5698, 2005.
• Kuroda,N., Mitani,T., Takeda,N., Sun,S., Kajiura,F., Mouri.,Y, Han,H., Matsushima,A., Yamada,G., and Matsumoto,M. Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice. J.Immunology. 174(4):1862-70, 2005
• Alappat,SR., Zhang,Z., Suzuki,K., Zhang,X., Liu,H., Jiang,R., Yamada,G. and Chen,Y. The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice. Dev Biol. 277:102-13, 2005.
• 宮川信一、松丸大輔、三原健一郎、村嶋亜紀、上村美佳、山田源．FGF遺伝子改変動物,492-497,臨床分子内分泌学3（日本臨床社）2005年63巻増刊号10
• Ogino,Y., Katoh,H. and Yamada,G. Androgen dependent development of a modified anal fin, gonopodium, as a model to understand the mechanism of secondary sexual character expression in vertebrates. FEBS Lett. 575:119-26, 2004.
• Satoh,Y., Haraguchi,R., Wright,T.J., Mansour,S.L., Partanen,J., Hajihosseini,M.K., Eswarakumar,V.P., Lonai,P., Yamada,G. Regulation of external genitalia development by concerted actions of FGF ligands and FGF receptors. Anat Embryol (Berl). 208:479-86, 2004.
• Suzuki,K., Shiota,K., Zhang,Y., Lei,L., Yamada,G.　　Development of the mouse external genitalia: unique model of organogenesis.　　Adv Exp Med Biol.545:159-72, 2004.
• Tucker,A., Watson,R.P., Lettice,L.A., Yamada,G. and Hill2, R.E. Bapx1 regulates patterning in the middle ear: Altered regulatory role in the transition from the proximal jaw during vertebrate evolution. Development 131, 1235-45, 2004.
• Itoh,H., Naganuma,S., Takeda,N., Miyata,S., Uchinokura,S., Fukushima,T., Uchiyama,S., Tanaka,H., Nagaike,K., Shimomura,T., Miyazawa,K., Yamada,G., Kitamura,N., Koono,M. and Kataoka,H. Regeneration of injured intestinal mucosa is impaired in hepatocyte growth factor activator-deficient mice.　Gastroenterology. 127:1423-35, 2004.
• Ozaki,H., Nakamura,K., Funahashi,J., Ikeda,K., Yamada,G., Tokano,H., Okamura,H., Kitamura,K., Muto,S., Kotaki,H., Sudo,K., Horai,R., Iwakura,Y. and Kawakami,K. Six1 controls patterning of the mouse otic vesicle. Development.131: 551-562,2004.
• 鈴木堅太郎、神川真美、尾木秀直、原口竜摩、荻野由紀子、山田源.　マウス外生殖器原基（生殖結節）にみられる伸長制御メカニズム：BMP signalingの 機能解析.　細胞工学　23:208-209, 2004.
• 太田将、鈴木堅太郎、立花克郎、山田源.　ソノポレーション法によるニワトリ胚への遺伝子導入.　細胞工学.　23(1): 94-99, 2004.
• 西田尚代、鈴木堅太郎、荻野由紀子、尾木秀直、田代浩徳、山田源。　　哺乳動物外生殖器の発生と分化制御　　化学と生物　　42(10): 666-672, 2004
• 太田将、尾木秀直、山田源。　外生殖器　　モデル動物の作成と維持　エル・アイ・シー　458-432　2004.7.10発行
• 尾木秀直、宮戸真美、太田将、篠原正徳、大場隆、山田源。　生殖器　モデル動物の作成と維持　エル・アイ・シー　911-913　2004.7.10発行
• 尾木秀直、鈴木堅太郎、篠原正徳、山田源. 外生殖器の発生分化と異常. 別冊・医学のあゆみ（疾患モデル動物）（編集　山村研一）　123-127, 2004.1.25発行.
• Suzuki,K., Bachiller,D., Chen,Y.P., Kamikawa,M., Ogi,H., Haraguchi,R., Ogino,Y., Mishina,Y., Ahn,K., Crenshaw,III E.B. and Yamada,G. Regulation of outgrowth and apoptosis for the terminal appendage, external genitalia, development by concerted functions of Bmp signaling. Development. 131: 6209-6220, 2003.
• Ohta,S., Suzuki,K., Tachibana,K., and Yamada,G. Microbubble-Enhanced Sonoporation; Efficient Gene Transduction Technique for Chick Embryos. Genesis. 37: 91-101, 2003 (cover page).
• Yamada,G., Satoh,Y., Baskin,LS. and Cunha,GR. Cellular and molecular mechanisms of development of the external Genitalia. Differentiation. 71: 445-60, 2003.
• Suzuki,K., Satoh,Y., Lei,L., Ohta,S., Urano,T., Nakagata,N. and Yamada,G. Developmental biology meets with reproductive engineering; interdisciplinar science area as a break through. Cell. Mol. Biol. 49: 653-660, 2003.
• Yamada,MO., Fujimori,K., Yamada,G., Satoh,H., Tohno,S., Tohno,Y., Moriwake,Y., Azuma,C., Minami,T. A special comment on trace metals in the viscera of turbo marmoratus, a toxic snail, on Ryukyu Island. Biol Trace Elem Res. 95:241-6, 2003.
• Yamada,M., Tohno,Y., Tohno,S., Utsumi,M., Moriwake,Y. and Yamada,G. Silicon Compatible with the Height of Human Vertebral Column. Biol Trace Elem Res. 95: 113-121, 2003.
• Oishi,I., Suzuki,H., Onishi,N., Takada,R., Kani,S., Ohkawara,B., Koshida,I., Suzuki,K., Yamada,G., Schwabe,GC., Mundlos,S., Shibuya,H., Takada,S. and Minami,Y. The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells., 8: 645-654, 2003.
• Yamazaki,S., Iwamoto,R., Saeki,K., Asakura,M., Takashima,S., Yamazaki,A., Kimura,R., Mizushima,H., Moribe,H., Higashiyama,S., Endoh,M., Kaneda,Y., Takagi,S., Itami,S., Takeda,N., Yamada,G. and Mekada,E. Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities. J Cell Biol. 163:469-75, 2003.
• 尾木秀直、鈴木堅太郎、篠原正徳、山田源. 外生殖器の発生分化と異常. 医学のあゆみ　205 (6), 423-427, 2003.
• 加藤洋教, 荻野由紀子, 山田源.　特集:小児医学のための発生学最前線　テーマ:15. 外性器形成の分子機構.　小児外科 35(3), 346-354, 2003.
• Komatsu,Y., Shibuya,H., Takeda,N., Ninomiya-Tsuji,J., Yasui,T., Miyado,K., Sekimoto,T., Ueno,N., Matsumoto,K., and Yamada,G. Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis. Mech Dev. 119: 239-249, 2002.
• Suzuki,K., Ogino,Y., Murakami,R., Satoh,Y. and Yamada,G. Embryonic development of mouse external genitalia; Insights into unique mode of organogenesis. EVOLUTION & DEVELOPMENT (Evo Dev)., 4:133-141, 2002.
• Rieger,F. and Yamada,G.(eds) Cell death in neurological disease. Cell. Mol. Biol., 48:125-217, 2002.
• 尾木秀直, 荻野由紀子, 篠原正徳, 山田源.　外生殖器の形態発生と異常. 小児科診療 65(10): 1665-1670, 2002.
• 荻野由紀子、加藤洋教、山田源：カダヤシ Gambusia affinis　　細胞工学 21(5): 522-523, 2002.
• Ogino,Y., Suzuki,K., Haraguchi,R., Satoh,Y., Dolle,P. and Yamada,G. External genitalia formation: Role of fibroblast growth factor, retinoic acid signaling and distal urethral epithelium (DUE). Ann NY Acad Sci, 948, 13-31, 2001.
• Haraguchi,R., Mo,R., Hui,Chi-chung., Motoyama,J., Makino,S., Shiroishi,T., Gaffield, W. and Yamada,G.　Unique functions of Sonic hedgehog signaling during external genitalia development. Development, 128, 4241-4250, 2001.
• Yamada,M., Fujimori,K., Yamada,G., Moriwake,Y., Tohno,S., Tohno,Y. Trace metals in vertebral columns of deep-sea teleost fish. BIOL TRACE ELEM RES 80: 245-249, 2001.
• 荻野由紀子、原口竜摩、加藤洋教、山田源. 外性器形成の分子メカニズム　医学のあゆみ 99(13): 1083-1089, 2001.
• Suzuki,K., Yamanishi,K., Mori,O., Kamikawa,M., Andersen,B., Kato,S., Toyoda,T. and Yamada, G. Defective terminal differentiation and hypoplasia of the epidermis in mice lacking the Fgf10 gene. FEBS Letter, 481, 53-56, 2000.
• Haraguchi,R., Suzuki,K., Murakami,R., Sakai,M., Kamikawa,M., Kengaku,M., Sekine,K., Kawano,H., Kato,S., Ueno,N. and Yamada,G. Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation. Development, 127, 2471-2479, 2000.
• *Miyado,K., *Yamada,G., *Yamada,S., Hasuwa,H., Nakamura,Y., Ryu,F., Suzuki,K., Kosai,K., Inoue,K., Ogura,A., Okabe,M. and Mekada,E.: Requirement of CD9 on the egg plasma membrane for fertilization. Science, 287, 321-324, 2000. *equaly contributed first author
• Yamada,MO., Okayama,M., Chikamori,K., Yamada,G., Moriwake,Y., Minami,T., Tohno,S., Takeuchi,R., Tohno,Y. Possible contaminant origins of the red cosmetics decorating ancient burial sites in Japan. Biol Trace Elem Res. 77(2):149-58, 2000.
• 原口竜摩、荻野由紀子、神川真美、鈴木堅太郎、長谷川太郎、一鬼勉、山田源.外性器形成過程の分子的解析；未知領域への挑戦　実験医学18:752-75, 2000.
• 原口竜摩、神川真美、鈴木堅太郎、荻野由紀子、竹田直樹、佐藤義彦、一鬼勉、村上柳太郎、山田源. 外性器形成過程の解析　細胞工学19(6):874-876, 2000.
  
• Yamada,G. (editor). Cellular and molecular mechanisms of organogenesis and early development. Cell. Mol. Biol., 45, 479-750, 1999.
• **Kuratani,S., Satokata,I., Blum,M., Komatsu,Y., Haraguchi,R., Nakamura,S., Suzuki,K., Kosai,K., Maas,R., Yamada, G. Middle ear defects associated with the double knock out mutation of murine goosecoid and Msx1 genes. Cell Mol Biol 45(5)., 589-99, 1999.
• Zhu,C.C., Yamada,G. and Blum,M. Retinoic acid teratogenicity: The role of goosecoid and BMP-4. Cell. Mol. Biol., 45, 617-630, 1999.
• Tucker,A., Yamada,G., Grigoriou,M., Pachnis,V. and Sharpe,P. Epithelial signals determine anterior-posterior polarity in the first branchial arch. Development, 126, 51-61, 1999.
• Miyama,K., Yamada,G., Miyado,K., Sakai,M., Ueno,N. and Shibuya,H. Essential role of a BMP-induced homeobox gene Dlx5 in osteoblast differentiation. Developmental Biol., 208, 123-133, 1999.
• Yamada,G., Nakamura,S., Terashi,T., Terai,K., Nomura,S., Kitamura,Y., Minami,T., Yamada,M-O., Suzuki,S., Izumi,H. and Nagata,R. Microphthalmia (mi) Mice Display an Aberrant Bone Trace Element Composition. Biol. Trace. Ele. Res. 62,75-82, 1998.
• Yamada,G., Nakamura,S., Haraguchi,R., Sakai,M., Suzuki,K., Miyado,K., Hasuwa,H., Ogino,Y., Minami,T., Tohno,Y., Blum,M. and Shultz,L. Aberrant regulation of bone trace elements in Motheaten (me) mice and Osteopetrosis (op) mice. Cell. Mol. Biol. 44, 315-319, 1998.
• Belo,J., Leyns,L., Yamada,G. and De Robertis,E. The prechordal midline of the chondrocranium is defective in Goosecoid-1 mouse mutants. Mech Development 26;72(1-2):15-25, 1998.
• Zhu,C*., Yamada,G*., Nakamura,S., Terashi,T., Schweickert,A. and Blum,M. Malformation of trachea, pelvic region and external genitalia in goosecoid mutant mice. *contributed equally to this work. Dev. Dyn. 211:374-381, 1998.
• Yamada,G. Nakamura,S., Fukuzaki,K., Izumi,H., Horai,N., Nagata,R., Minami,T., Tohno,Y., Suzuki, K., Haraguchi,R., Toyoda,T., Izpisua-Belmonte,J.-C., Maruyama, I. and Kitajima,I. Dysregulation of Trace Element Composition in Ovariectomized Cynomolgus Monkey Bones. Cell. Mol. Biol. 44, 1205-1213, 1998
• Yamada,G., Sugimura,K., Nakamura,S., Yamada,M-O., Tohno,Y., Maruyama,I., Kitajima,I. and Minami,T. Metal Composition and Histological Analysis of the Rat Bones from Space Shuttle. Life Sciences 60, 635-642, 1997
• Yamada,G., Ueno,K., Nakamura,S., Eizuru,Y., Hanamure,Y., Mansouri,A., Yasui,K., Uemura,M., Blum,M. and Sugimura,K. Nasal and pharyngeal abnormalities caused by the mouse Goosecoid gene mutation. Biochem Biophys Res Commun., 233, 161-165, 1997
• Yamada,M-O., Minami,T., Yamada,G., Tohno,Y., Tohno,S., Ikeda,Y., Tashiro,T., Kohno,Y. and Kawakami,K. Different element ratios of red cosmetics excavated from ancient burials of Japan. The Science of the Total Environment 199, 293-298, 1997
• Fukumoto,T., Torigoe,N., Kawabata,S., Kaneko,Y., Murakami,M., Uede,T., Nishi,T., Yamada,G. and Sugimura,K. Ligand-binding activity of phage clones captured by anti-receptor antibody from phage display library. Peptide Chemistry ( C.Kitada eds., Protein Res. Foundation) 313-316, 1997.
• Zhu,C., Yamada,G. and Blum,M. Correlation between loss of middle ear bones and altered goosecoid gene expression in the branchial region following retinoic acid treatment of mouse embryos in vivo. Biochem Biophys Res Commun., 235, 748-753, 1997.
• Fujimori,K., Yamada,G.. Yamada,M.O., Minami,T., Tohno,S. and Tohno,Y. A periodical change of mercury in the coral reef, Heliofungia species obtained from the Okinawa sea. Cell. Mol. Biol. 43, 809-811, 1997.
• Yamada,G., Nakamura,S., Haraguchi,R., Sakai,M., Terashi,T., Sakisaka,S., Toyoda,T., Ogino,Y., Hatanaka,H. and Kaneda,Y. An efficient liposome-mediated gene trasnsfer into the branchial arch, neural tube and the heart of chick embryos; A strategy to elucidate the organogenesis. Cell. Mol. Biol., 43 , 1165-1169, 1997.
• Tohno,S., Tohno,Y., Minami,T., Okazaki,Y., Utsumi,M., Nishiwaki,F., Moriwake,Y., Yamada,M.O. and Yamada,G. Differential accumulation of calcium and phosphorus in aged human arteries. Acta. Anat. Nippon, 72, 451-454, 1997.
• Hashiguchi,S., Hino,K., Taniguchi,Y., Fukuda,K., Ohyama,M., Fujiyoshi,T., Sonoda,S., Yamada,G. and Sugimura,K. Determination of T cell epitopes of a Japanese Ceder Pollen, Cry j2. Peptide Chemistry (N. Nishi eds., Protein Res. Foundation) 409-412, 1996
• Torigoe,N., Kaneko,Y., Murakami,M., Uede,T., Nishi,T., Yamada,G. and Sugimura,K. CD80(B7-1)-Binding Fd phage clones selected from random display library. Peptide Chemistry (N. Nishi eds., Protein Res. Foundation) pp405-408, 1996
• Hashiguchi,S., Hino,K., Taniguchi,Y., Kurimoto,M., Fukuda,K., Ohyama,M., Fujiyoshi,T., Sonoda,S., Nishimura,Y., Yamada,G. and Sugimura,K. Immuno-dominance of seven regions of a major allergen, Cry j2 from Japanese cedar pollen for T cell immunity. Allergy 51, 621-632, 1996
• Yamada,G., Sugimura,K., Minami,T., Yamada,M-O., Okazaki,Y., Pituello,F., Takasaki,I., Maruyama,I. and Kitajima,I. Senescence-accelerated mouse (SAM) displays aberrant bone metal composition. Pharmaceutical Sci. 2, 305-306, 1996
• Sugimura,K., Hashiguchi,S., Takahashi,Y., Hino,K., Taniguchi,Y., Kurimoto,M., Fukuda,K., Ohyama,M. and Yamada,G. Th1/Th2 response profiles to the major allergens, Cry j1 and Cry j2 from Japanese cedar pollen. Allergy 51, 732-740, 1996
• Yamada,G., Shimoo,K., Takashina,M., Eto,Y., Abe,H., Kioussi,C., Lindstrom,L. and Sugimura,K. Evaluation of cellular responses to growth factors and collagen treated materials by RNA-in situ hybridization. Pharmaceutical Sci. 2, 185-188, 1996
• Pituello,F., Yamada,G. and Gruss,P. Activin A inhibits Pax-6 expression and perturbs cell differentiation in the developing spinal cord in vitro. Proc.Natl.Acad.Sci.USA. 92,6952-6956, 1995
• Yamada,G., Mansouri,A., Torres,M., T.Stuart,E., Blum,M., Schultz,M., De Robertis,E.M. and Gruss,P. Targeted mutation of the mouse goosecoid gene leads to neonatal death and craniofacial defects. Development 121, 2917-2922, 1995
• Yamada,G., Kioussi,C., Schubert,F., Eto,Y., Chowdhury,K., Pituello,F. and Gruss,P. Regulated expression of Brachyury(T), Nkx1.1 and Pax genes by ES cell derived embryoid bodies. Biochem Biophys Res Commun.,199, 552-563, 1994.
• Kioussi,C. and Yamada,G. Double labeling detection of a protein marker and mRNA in ES cell derived embryoid bodies. J.Tiss.Cul.Meth. ,16, 11-16, 1994.
• Yamada,G., Sugimura,K. and Stuart,E.T. Gene targeting approach to study the cellular process for growth or differentiation: adances in the analysis of oncogenes, tumor suppressor genes, cytokine/receptor systems and developmental control genes. Eur.J.Biochem.,226, 739-749, 1994.
• Yamada,G., Ogawa,M., Akagi,K., Miyamoto,H., Nakano,N., Itoh,S., Miyazaki,J., Nishikawa,S., Yamamura,K. and Taniguchi,T. Specific depletion of B cell population induced by aberrant expression of human interferon regulatory factor 1 gene in transgenic mice. Proc.Nat.Acad.Sci.USA 88, 532-536, 1991.
• Bacha,P., Forte,S.E. McCarthy,M.D., Estis,L., Yamada,G. and Nichols,C.J. Impact of Interleukin 2 receptor targeted cytotoxins on a unique model of murine IL2 receptor expressing malignancy. Int.J.Cancer 49, 96-101, 1991.
• Miyazaki,T., Maruyama,M., Yamada,G., Hatakeyama,M. and Taniguchi,T. The integrity of conserved WS motif common to IL2 and other cytokine receptors is essential for ligand binding and signal transduction. EMBO.J.10, 3191-3197, 1991.
• Kono,T., Doi,T., Yamada,G., Hatakeyama,M., Minamoto,S., Tsudo,M., Miyasaka,M. and Taniguchi,T. Murine IL2 receptor beta chain: Dysregulated gene expression in lymphoma line EL4 caused by a promoter insertion. Proc.Natl.Acad.Sci.USA 87,1806-1810, 1990.
• Yamada,G., Kitamura,Y., Sonoda,H., Harada,H., Taki,S., Mulligan,RC., Osawa,H., Diamantstein,T., Yokoyama,S. and Taniguchi,T. Retroviral expression of the human IL2 gene in a murine T cell line results in cell growth autonomy and tumorgenicity. EMBO.J. 6, 2705-2709, 1987.
• Taniguchi,T., Fujita,T., Hatakeyama,M., Mori,M., Matsui,H., Sato,T., Hamuro,J., Minamoto,S., Yamada,G. and Shibuya,H. IL2 and its receptor: Structure and functional expression of the genes. Cold Spring Harbor Symposia on Quantitative Biology LI ,577-586, 1986.
• Taniguchi,T., Matsui,H., Fujita,T., Hatakeyama,M., Kashima,N., Fuse,A., Hamuro,J., Takaoka,C. and Yamada,G. Molecular analysis of the Interleukin 2 system. Immunol.Rev. 92, 121-133, 1986.
• Takatsu,K., Harada,N., Hara,Y., Takahama,Y., Yamada,G., Dobashi,K. and Hamaoka, T. Purification and physicochemical characterization of murine T cell replacing factor (TRF). J.Immunol. 134, 382-389, 1985.
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