Publications
2017
A comparative study of the inhibitory effects by caffeic acid, catechins and their related compounds on the generation of radicals in the reaction mixture of linoleic acid with iron ions. Yuji Matsui, Yoshie Tanaka and Hideo Iwahashi, J. Clin. Biochem. Nutr. 2017, 60: 162-168.
Determination of the structures of radicals formed in the reaction of antimalarial drug artemisinin with ferrous ions. Marie Asano and Hideo Iwahashi, European Journal of Medicinal Chemistry 2017, 127: 740-747.
2016
Radical formation in the FMN-photosensitized reactions of unsaturated fatty acids bearing double bonds at different positions. Nao Nishihama and Hideo Iwahashi, Journal of Chromatography B 2016,1028: 216-221.
Characterization of radicals arising from oxidation of commercially-important essential oils. Hiroko-Miyuki Mori and Hideo Iwahashi, Free Radical Research 2016, 75: 156-166.
2015
Baicalin inhibits the Fenton reaction by enhancing electron transfer from Fe2+ to dissolved oxygen. Daisuke Nishizaki, Hideo Iwahashi, American Journal of Chinese Medicine 2015, 42: 87-101.
2014
Caffeic acid inhibits the formation of 7-carboxyheptyl radicals from oleic acid under flavin mononucleotide photosensitization by scavenging singlet oxygen and quenching the excited state of flavin mononucleotide. Marie Asano and Hideo Iwahashi, Molecules 2014, 19: 12486-12499.
2013
Detection and identification of 1-methylethyl and methyl radicals generated by irradiating tea tree (Melaleuca alternifolia) oil with visible light (436 nm) in the presence of flavin mononucleotide and ferrous ion. H.-M. Mori and H. Iwahashi, Free Radical Research 2013, 47: 657?663.
2012
ONIOM study of a proton shuttle-catalyzed stepwise mechanism for peptide bond formation in the ribosome. Kazuaki Fukushima, Hideo Iwahashi and Morimitsu Nishikimi, Bull. Chem. Soc. Jpn. 2012, 85: 1093-1101.
Identification of the radicals formed in the reactions of some endogenous photosensitizers with oleic acid under the UVA irradiation. Hiroko Mori and Hideo Iwahashi, J. Clin. Biochem. Nutr. 2012, 51: 170-177.
2011
Formation of 7-carboxyheptyl radical induced by singlet oxigen in the reaction mixture of oleic acid, riboflavin and ferrous ion under the UVA irradiation.
Hiroko Mori and Hideo Iwahashi, J Clin Biochem Nutr. (In Press.)
Caffeic Acid Inhibits the Formation of 1-Hydroxyethyl Radical in the Reaction Mixture of Rat Liver Microsomes with Ethanol Partly through Its Metal Chelating.
Hideyuki Ikeda, Yuka Kimura, Miho Masaki and Hideo Iwahashi, J Clin Biochem Nutr. (In Press.)
2010
Detection of the reduced forms of radical adducts on the ESR trace using HPLC-electrochemical detector-ultraviolet absorption detector-electron spin resonance-MS.
Hideyuki Ikeda and Hideo Iwahashi, J. Sep. Sci. 2010, 33: 1185-1191.
Identification of a Radical Formed in the Reaction Mixtures of Ram Seminal Vesicle Microsomes with Arachidonic Acid Using High Performance Liquid Chromatography-Electron Spin Resonance Spectrometry and High Performance Liquid Chromatography-Electron Spin Resonance-Mass Spectrometry.
Katsuyuki Minakata and Hideo Iwahashi, J Clin Biochem Nutr. 2010, 46: 135-139.
2009
リボフラビン溶液中へのUVA照射によるスーパーオキシド産生に対する各種精油(エッセンシャルオイル)の効果 森 広子, 岩橋 秀夫 日本補完代替医療学会誌. 6, 151-156, (2009)
Identification of Radicals Formed in the Reaction Mixture of Bovine Kidney Microsomes with NADPH.
Kazumasa Kumamoto, Tomihiro Hirai, Shiroh Kishioka, Hideo Iwahashi, J Biochem, 2009, 146: 571-579.
Antioxidant Activity of Caffeic Acid through a Novel Mechanism under UVA Irradiation.
Hiroko Mori and Hideo Iwahashi, J Clin Biochem Nutr. 2009, 45: 49-55.
8-Oxo-7,8-dihydro-2-deoxyguanosine forms a relatively unstable tetrameric structure compared with 2-deoxyguanosine. H. Iwahashi, J. Clin. Biochem. Nutr. 44, 57-61 (2009)
Optimization of Excited State Geometries and Simulation of UV Spectra of Polyenes with Gaussian 09, K. Fukushima Bulletin of Wakayama Medical University (Liberal Arts and Sciences) , 39, 1-11 (2009).
2008
High Performance Liquid Chromatography/Electron Spin Resonance/Mass Spectrometry Analysis of Lipid-Derived Radicals. H. Iwahashi, Methods Mol Biol. 477, 65-73, (2008)
Superoxide Dismutase Enhances The Formation of Hydroxyl Radicals in The Reaction Mixture Containing Xanthone under UVA Irradiation. H. Mori, H. Iwahashi, Biosci. Biotechnol. Biochem. 71, 3014-3018 (2008)
Theoretical Study of Effect of General Acid Base Catalysts on Hydrolysis of Ester, K. Fukushima Bulletin of Wakayama Medical University (Liberal Arts and Sciences) , 38, 19-30 (2008).
2007
Identification of Radicals Formed in The Reaction Mixtures of Rat Liver Microsomes with ADP, Fe3+, and NADPH using HPLC-EPR and HPLC-EPR-MS. K. Minakata, E. Okuno, M. Nakamura, H. Iwahashi, J. Biochem. 142, 73-78 (2007)
Identification of A Radical Formed in The Reaction Mixture of Rat Brain Homogenate with A Ferrous Ion/Ascorbic Acid System Using HPLC-EPR and HPLC-EPR-MS. K. Kumamoto, T. Hirai, S. Kishioka, H. Iwahashi, Free Rad. Res. 41, 650-654 (2007)
Benchmark of Molecular Mechanics, Semiempirical Molecular Orbital Theory, Hartree-Fock Theory, Density Functional Theory, and Perturbation Theory Calculations for Hydrogen-Bonding Pairs of Nucleic Acid Bases, K. Fukushima Bulletin of Wakayama Medical University (Liberal Arts and Sciences) , 37, 9-20 (2007).
2006
Enhancement by Cigarette Smoke Extract of The Radical Formation in A Reaction Mixture of 13-Hydroperoxide Octadecadienoic Acid and Ferric Ions. S. Iimura, H. lwahashi, J. Biochem. 139, 671-676 (2006)
High Performance Liquid Chromatography/Electron Spin Resonance/mass Spectrometry Analyses of Radicals Formed in An Anaerobic Reaction of 9- (or 13-) Hydroperoxide Octadecadienoic Acids with Ferrous Ions. H. Iwahashi, T. Hirai, K. Kumamoto, J Chromatogr A, 1132, 67-75 (2006)
Substituent Effects on Two Orthogonal π-Systems in Pseudopericyclcic Ring-opening Reaction s of 5-Alkoxy-2-aminooxazoles, Kazuaki Fukushima and Hideo Iwahashi, Chem. Lett., 35, 1242-1243 (2006).
Counterpoise Correction of Association Energy of Hydrogen-bonding Complexes, K. Fukushima Bulletin of Wakayama Medical University (Liberal Arts and Sciences) , 36, 1-9 (2006).
2005
Identification of a radical formed in the reaction mixtures of oxidized phosphatidylcholine with ferrous ions using HPLC-ESR and HPLC-ESR-MS. Kumamoto K, Hirai T, Kishioka S, Iwahashi H. Free Radic Res. 2005 Sep;39(9):987-93.
Effects of some naturally occurring iron ion chelators on in vitro superoxide radical formation, T. Hirai, K. Fukushima, K. Kumamoto, H. Iwahashi, Biol. Trace Elem. Res., 108, 77-86 (2005).
Natural Bond Orbital Analysis of Pericyclic and Pseudopericyclic 1,5-Electrocyclizations of Conjugated Azides, K. Fukushima, H. Iwahashi, Heterocycles, 65, 2605-2618 (2005).
Efficient Catalytic Effects of Lewis Acids in the 1,3-Dipolar Cycloaddition Reactions of Carbonyl Ylides with Imines, Hiroyuki Suga, Yasutaka Ebiura, Kazuaki Fukushima, Akikazu Kakehi, and Toshihide Baba, J. Org. Chem., 70, 10782 - 10791 (2005).
Effect of Counterpoise Correction on Formation of Hydrogen-bonded Dimer of Formic Acid, K. Fukushima Bulletin of Wakayama Medical University (Liberal Arts and Sciences) , 35, 1-16 (2005).
2004
The Inhibitory Effect of Luteolin-7-O-glucoside on the Formation of Pentyl and 7-Carboxyheptyl Radicals from 13-Hydroperoxy-9,11-octadecadienoic Acid in the Presence of Iron(II) Ions
Iwahashi H, Akata K, Sunaga A, Tone Y, Yamada N, Iijima K. Free Radic Res. 2004 Aug;38(8):869-76.
Identification of 1-ethoxyethyl radicals in the reaction of ferrous ions with serums from rats exposed to diethyl ether. Kumamoto K, Hirai T, Kishioka S, Iwahashi H. Toxicol Lett. 2004 Dec 30;154(3):235-9.
Natural Bond Orbital Analysis of Pericyclic and Pseudopericyclic 1,5-Electrocyclizations of Conjugated Nitrileimines, K. Fukushima, H. Iwahashi, Bull. Chem. Soc. Jpn., 77, 1671-1679 (2004).
Evaluation of Basis Set Superposition Error in 1,3-Dipolar Cycloaddition of Nitrile Ylide with Ethylene by Counterpoise Correction, K. Fukushima Bulletin of Wakayama Medical University (Liberal Arts and Sciences) , 34, 1-10 (2004).
2003
Identification of the several new radicals formed in the reaction mixture of oxidized linoleic acid with ferrous ions using HPLC-ESR and HPLC-ESR-MS. H.Iwahashi, Free Rad. Res., 37, 939-945 (2003).
The formation of the 7-carboxyheptyl radical from 13-hydroperoxy-9,11-octadecadienoic acid catalyzed by hemoglobin and myoglobin under anaerobic conditions. H.Iwahashi, K. Kumamoto, T. Hirai, J. Biochem., 133, 679-685 (2003).
銅結合プリオンタンパク質によるニトロソチオール分解の促進. 白石則之，岩橋秀夫，錦見盛光, Biomed. Res. Trace Elements, 14, 353〜355 (2003).
Natural Bond Orbital Analysis of 1,5-Electrocyclizations of Vinyl and Formyldiazomethanes, K. Fukushima, Bulletin of Wakayama Medical University (Liberal Arts and Sciences), 33, 13-28 (2003).
2002
Detection of the radical and reduced forms of _-(4- pyridyl 1-oxide)-N-tert-butylnitrone/pentyl radical adduct formed on the reaction of an oxidized linoleic acid with ferrous ions using high performance liquid chromatography with electrochemical detection. H.Iwahashi, K. Nishizaki, I. Takagi, J. Sep. Sci., 25, 601〜607 (2002).
Cytochrome c catalises the formation of pentyl radical and octanoic acid radical from linoleic acid hydroperoxide. H.Iwahashi, K. Nishizaki, I. Takagi, Biochem. J., 361, 57-66 (2002).
NBO Analysis of Pericyclic and Pseudopericyclic 1,5-Electorcyclizations of Conjugated Nitrile Ylides, K. Fukushima, Bulletin of Wakayama Medical University (Liberal Arts and Sciences), 32, 25-35 (2002).
2001
Ascorbate-induced high-affinity binding of copper to cytosolic protein. Y. Ohta, N. Shiraishi, Y. Inai, I. Matsui, H.Iwahashi, M. Nishikimi, Biochem. Biophys. Res. Commun., 287, 888-894 (2001).
Electronic Properties of Pericyclic and Pseudopericyclic 1,5-Electorcyclizations of Conjugated Nitrile Ylides, K. Fukushima, Bulletin of Wakayama Medical University (Liberal Arts and Sciences), 31, 17-25 (2001).
2000
High-performance liquid chromatographic determination of linoleic acid peroxide-derived radicals using electrochemical detection. H.Iwahashi, J. Chromatogr. A, 904, 197-202 (2000).
Some polyphenols inhibit the formation of pentyl radical and octanoic acid radical in the reaction mixture of linoleic acid hydroperoxide with ferrous ions. H.Iwahashi, Biochem. J., 346, 265-273 (2000).
1+1 Complex of guanine quartet with alkali metal cations detected by electrospray ionization mass spectrometry. K. Fukushima, H.Iwahashi, Chem. Commun., 895-896 (2000).
Molecular Orbital Calculations on Ground State Nitrilium Betaines, K. Fukushima, Bulletin of Wakayama Medical University (Liberal Arts and Sciences), 30, 25-34 (2000).
Density Functional Studies of 1,5-Cyclization of 3-Carbonyl Nitrile Ylide, K. Fukushima, Bulletin of Wakayama Medical College (Liberal Arts and Sciences), 29, 61-70 (1999).
1999
3-Hydroxyanthranilic acid-derived compounds formed through electrochemical oxidation. H.Iwahashi, T. Ishii , J. Chromatogr. A, 773, 23-31 (1999).
Quinolic acid, α-picolinic acid, fusaric acid, and 2,6-pyridinedicarboxylic acid enhance the Fenton reaction in phosphate buffer. H.Iwahashi, H. Kawamori, K. Fukushima, Chemico-Biological Interactions, 118, 201-215 (1999).
1998
フリーラジカル生成と生体内反応. 岩橋秀夫, 外科と代謝・栄養, 32, 327-334 (1998).
Ab Initio and Density Functional Studies of Nitrile Ylide and 3-Formyl Nitrile Ylide, K. FUKUSHIMA, Bulletin of Wakayama Medical College (Premedical School), 28, 65-81 (1998).
1997
Detection of the oxidative products of 3-hydroxykynurenine using high-performance liquid chromatography-electrochemical detection-ultraviolet absorption detection-electron spin resonance spectrometry and high-performance liquid chromatography-electrochemical detection-ultraviolet absorption detection-mass spectrometry. H.Iwahashi, J. Chromatogr. A, 773, 237-245 (1997).
Nitrile Ylide Mechanism in Formal [3+2] Additions of Activated Oxazole, K. FUKUSHIMA and T. IBATA, Bulletin of Wakayama Medical College (Premedical School), 27, 43-54 (1997).
1996
Quantitative detection of reduced, radical and oxidized forms of _-(4-pyridyl-1-oxide)-N-tert-butylnitron radical adduct using high-performance liquid chromatography with electrochemical detection. H.Iwahashi, J. Chromatogr. A, 753, 235-242 (1996).
Identification of radical adducts formed in the reactions of unsaturated fatty acids with soybean lipoxygenase using continuous flow atom bombardment with tandem mass spectrometry. H.Iwahashi, L. Deterding, C. Parker, R. Mason, K. Tomer, Free Rad. Res. , 255-274 (1996).
スピンアダクトのMS/MS分析とその壊裂パターン. 岩橋秀夫, 和歌山県立医科大学進学課程紀要，25, 49-60 (1996).