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教員情報

氏名 伊東 秀文(イトウ ヒデフミ)
所属 神経内科学講座
職名 教授
連絡先
電話番号
073-441-0654
FAX番号
073-447-9488
主な担当科目 神経内科学
主な研究テーマ 神経変性疾患の分子神経病理学的研究
疾患特異的iPS細胞と剖検脳を用いた神経変性疾患の病態解明
筋萎縮性側索硬化症の神経変性機序解明と新規治療薬の開発
パーキンソン病とその類縁疾患における黒質細胞死抑制と再生に関する研究
研究分野
(キーワード)
臨床神経学
神経病理学
分子神経病態学
神経変性疾患
脳機能手術
略歴 昭和59年 3月  京都大学医学部 卒業
昭和59年 6月  京都大学医学部附属病院 神経内科学講座
昭和60年 6月  財団法人田附興風会医学研究所 北野病院 神経内科
平成 元年11月 ニューヨーク市 アルバート・アインシュタイン医科大学付属
モンテフィオーレ医学研究所 神経病理学研究室 Research Fellow
平成 3年11月  財団法人田附興風会医学研究所 北野病院 神経内科 副部長
平成10年 4月  関西医科大学 神経内科学講座
平成12年 8月  関西医科大学 神経内科学講座 助教授(准教授)
平成20年10月   京都大学大学院医学研究科 脳病態生理学講座 臨床神経学 講師
平成24年 7月  和歌山県立医科大学 神経内科学講座 教授
主な著書・論文
(最近3年間)
1. Nakamura S, Wate R, Kaneko S, Ito H, Oki M, Tsuge A, Nagashima M, Asayama S, Fujita K, Nakamura M, Maruyama H, Kawakami H, Kusaka H: An autopsy case of sporadic amyotrophic lateral sclerosis associated with the I113T SOD1 mutation. Neuropathology. 2013 Jun 17.
2. Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MC, Gage FH, Yamanaka S, Inoue H: Response to Comment on "Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells". Sci Transl Med. 2013 Jun 5;5(188):188lr2.
3. Akizuki M, Yamashita H, Uemura K, Maruyama H, Kawakami H, Ito H, Takahashi R: Optineurin suppression causes neuronal cell death via NF-κB pathway.  J Neurochem. 2013 May 30.
4. Shodai A, Morimura T, Ido A, Uchida T, Ayaki T, Takahashi R, Kitazawa S, Suzuki S, Shirouzu M, Kigawa T, Muto Y, Yokoyama S, Takahashi R, Kitahara R, Ito H, Fujiwara N, Urushitani M: Aberrant assembly of RNA-recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein-43 (TDP-43). J Biol Chem. 2013 May 24;288(21):14886-905.
5. Matsui H, Sato F, Sato S, Koike M, Taruno Y, Saiki S, Funayama M, Ito H, Taniguchi Y, Uemura N, Toyoda A, Sakaki Y, Takeda S, Uchiyama Y, Hattori N, Takahashi R: ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons. FEBS Lett. 2013 May 2;587(9):1316-25.
6. Matsui H, Gavinio R, Asano T, Uemura N, Ito H, Taniguchi Y, Kobayashi Y, Maki T, Shen J, Takeda S, Uemura K, Yamakado H, Takahashi R: PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates. Hum Mol Genet. 2013 Jun 15;22(12):2423-34.
7. Shodai A, Ido A, Fujiwara N, Ayaki T, Morimura T, Oono M, Uchida T, Takahashi Y, Ito H, Urushitani M: Conserved Acidic Amino Acid Residues in a Second RNA Recognition Motif Regulate Assembly and Function of TDP-43. PLoS One 2012 Dec;7(12):e52776
8. Tashiro Y, Urushitani M, Inoue H, Koike M, Uchiyama Y, Komatsu M, Tanaka K, Yamazaki M, Abe M, Misawa H, Sakimura K, Ito H, Takahashi R: Motor Neuron-specific Disruption of Proteasomes, but Not Autophagy, Replicates Amyotrophic Lateral Sclerosis. J Biol Chem. 2012 Dec 14;287(51):42984-94.
9. Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MC, Gage FH, Yamanaka S, Inoue H: Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci Transl Med. 2012 Aug 1;4(145):145ra104
10. Ishiura H, Sako W, Yoshida M, Kawarai T, Tanabe O, Goto J, Takahashi Y, Date H, Mitsui J, Ahsan B, Ichikawa Y, Iwata A, Yoshino H, Izumi Y, Fujita K, Maeda K, Goto S, Koizumi H, Morigaki R, Ikemura M, Yamauchi N, Murayama S, Nicholson GA, Ito H, Sobue G, Nakagawa M, Kaji R, Tsuji S: The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal dominant involvement. Am J Hum Genet. 2012 Aug 10;91(2):320-9.
11. Nakamura M, Kaneko S, Wate R, Asayama S, Nakamura Y, Fujita K, Ito H, Kusaka H: Regionally different immunoreactivity for Smurf2 and pSmad2/3 in TDP-43-positive inclusions of amyotrophic lateral sclerosis. Neuropathol Appl Neurobiol. 2012 Mar 21
12. Nakamura M, Kaneko S, Ito H, Jiang S, Fujita K, Wate R, Nakano S, Fujisawa JI, Kusaka H: Activation of Transforming Growth Factor-β/Smad Signaling Reduces Aggregate Formation of Mislocalized TAR DNA-Binding Protein-43. Neurodegener Dis. 2012 Jul 10.
13. Honjo Y, Ito H, Horibe T, Shimada H, Nakanishi A, Mori H, Takahashi R, Kawakami K: Derlin-1-immunopositive inclusions in patients with Alzheimer's disease. Neuroreport. 2012 Jul 11;23(10):611-5.
14. Sako W, Ito H, Yoshida M, Koizumi H, Kamada M, Fujita K, Hashizume Y, Izumi Y, Kaji R: Nuclear factor κ B expression in patients with sporadic amyotrophic lateral sclerosis and hereditary amyotrophic lateral sclerosis with optineurin mutations. Clin Neuropathol. 2012 Nov-Dec;31(6):418-23.
15. Kawamoto Y, Ito H, Ihara M, Takahashi R: Immunohistochemical localization of X-linked inhibitor of apoptosis protein in brainstem-type and cortical Lewy bodies. Neuroreport. 2012 Feb 15;23(3):162-7.
16. Kasahara S, Miki Y, Kanagaki M, Kondo T, Yamamoto A, Morimoto E, Okada T, Ito H, Takahashi R, Togashi K: "Hot cross bun" sign in multiple system atrophy with predominant cerebellar ataxia: a comparison between proton density-weighted imaging and T2-weighted imaging. Eur J Radiol. 2012 Oct;81(10):2848-52.
17. Hase Y, Okamoto Y, Fujita Y, Kitamura A, Nakabayashi H, Ito H, Maki T, Washida K, Takahashi R, Ihara M: Cilostazol, a phosphodiesterase inhibitor, prevents no-reflow and hemorrhage in mice with focal cerebral ischemia. Exp Neurol. 2012 Jan;233(1):523-33.
18. Okamoto Y, Yamamoto T, Kalaria RN, Senzaki H, Maki T, Hase Y, Kitamura A, Washida K, Yamada M, Ito H, Tomimoto H, Takahashi R, Ihara M: Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts. Acta Neuropathol. 2012 Mar;123(3):381-94.
19. Kitamura A, Fujita Y, Oishi N, Kalaria RN, Washida K, Maki T, Okamoto Y, Hase Y, Yamada M, Takahashi J, Ito H, Tomimoto H, Fukuyama H, Takahashi R, Ihara M: Selective white matter abnormalities in a novel rat model of vascular dementia. Neurobiol Aging. 2012 May;33(5):1012.e25-35.
20. Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Asada M, Watanabe K, Hayashida N, Ihara M, Ito H, Shimohama S, Kihara T, Kinoshita A: Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice. Neurobiol Aging. 2012 May;33(5):1011.e11-23.
21. Nakamura M, Ito H, Nakamura Y, Wate R, Kaneko S, Nakano S, Matsumoto S, Kusaka H: Smad ubiquitination regulatory factor-2 in progressive supranuclear palsy. Neuropathol Appl Neurobiol. 2011 Apr;37(3):307-14.
22. Okamoto Y, Ihara M, Urushitani M, Yamashita H, Kondo T, Tanigaki A, Oono M, Kawamata J, Ikemoto A, Kawamoto Y, Takahashi R, Ito H: An autopsy case of SOD1-related ALS with TDP-43 positive inclusions. Neurology. 2011 Nov 29;77(22):1993-5.
23. Honjo Y, Kaneko S, Ito H, Horibe T, Nagashima M, Nakamura M, Fujita K, Takahashi R, Kusaka H, Kawakami K: Protein disulfide isomerase-immunopositive inclusions in patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2011 Nov;12(6):444-50.
24. Honjo Y, Ito H, Horibe T, Takahashi R, Kawakami K: Protein disulfide isomerase immunopositive glial cytoplasmic inclusions in patients with multiple system atrophy. Int J Neurosci. 2011 Oct;121(10):543-50.
25. Okamoto Y, Shirakashi Y, Ihara M, Urushitani M, Oono M, Kawamoto Y, Yamashita H, Shimohama S, Kato S, Hirano A, Tomimoto H, Ito H, Takahashi R: Colocalization of 14-3-3 proteins with SOD1 in Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model. PLoS One. 2011;6(5):e20427.
26. Ito H, Nakamura M, Komure O, Ayaki T, Wate R, Maruyama H, Nakamura Y, Fujita K, Kaneko S, Okamoto Y, Ihara M, Konishi T, Ogasawara K, Hirano A, Kusaka H, Kaji R, Takahashi R, Kawakami H: Clinicopathologic study on an ALS family with a heterozygous E478G optineurin mutation. Acta Neuropathol. 2011 Aug;122(2):223-9.
27. Maki T, Wakita H, Mase M, Itagaki I, Saito N, Ono F, Adachi K, Ito H, Takahashi R, Ihara M, Tomimoto H: Watershed infarcts in a multiple microembolic model of monkey. Neurosci Lett. 2011 Jul 20;499(2):80-3.
28. Maki T, Ihara M, Fujita Y, Nambu T, Harada H, Ito H, Nakao K, Tomimoto H, Takahashi R: Angiogenic roles of adrenomedullin through vascular endothelial growth factor induction. Neuroreport. 2011 Jun 22;22(9):442-7.
29. Maki T, Ihara M, Fujita Y, Nambu T, Miyashita K, Yamada M, Washida K, Nishio K, Ito H, Harada H, Yokoi H, Arai H, Itoh H, Nakao K, Takahashi R, Tomimoto H: Angiogenic and vasoprotective effects of adrenomedullin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice. Stroke. 2011 Apr;42(4):1122-8.
30. Ito H, Fujita K, Nakamura M, Wate R, Kaneko S, Sasaki S, Yamane K, Suzuki N, Aoki M, Shibata N, Togashi S, Kawata A, Mochizuki Y, Mizutani T, Maruyama H, Hirano A, Takahashi R, Kawakami H, Kusaka H: Optineurin is co-localized with FUS in basophilic inclusions of ALS with FUS mutation and in basophilic inclusion body disease. Acta Neuropathol. 2011 Apr;121(4):555-7.
31. Yamada M, Ihara M, Okamoto Y, Maki T, Washida K, Kitamura A, Hase Y, Ito H, Takao K, Miyakawa T, Kalaria RN, Tomimoto H, Takahashi R: The influence of chronic cerebral hypoperfusion on cognitive function and amyloid β metabolism in APP overexpressing mice. PLoS One. 2011 Jan 27;6(1):e16567.
32. Saito S, Ozaki A, Takahashi M, Ito H, Matsumoto S, Tomimoto H: Clustering of multifocal cerebral infarctions in CADASIL: a case report. J Neurol. 2011 Feb;258(2):325-7.
33. Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, Kinoshita Y, Kamada M, Nodera H, Suzuki H, Komure O, Matsuura S, Kobatake K, Morimoto N, Abe K, Suzuki N, Aoki M, Kawata A, Hirai T, Kato T, Ogasawara K, Hirano A, Takumi T, Kusaka H, Hagiwara K, Kaji R, Kawakami H: Mutations of optineurin in amyotrophic lateral sclerosis. Nature. 2010 May 13;465(7295):223-6.
34. Kawamoto Y, Ito H, Kobayashi Y, Suzuki Y, Takahashi R: Localization of HtrA2/Omi immunoreactivity in brains affected by Alzheimer's disease. Neuroreport. 2010 Dec 8;21(17):1121-5.
35. Matsui H, Ito H, Taniguchi Y, Takeda S, Takahashi R: Ammonium chloride and tunicamycin are novel toxins for dopaminergic neurons and induce Parkinson's disease-like phenotypes in medaka fish. J Neurochem. 2010 Dec;115(5):1150-60.
36. Matsui H, Ito H, Taniguchi Y, Inoue H, Takeda S, Takahashi R: Proteasome inhibition in medaka brain induces the features of Parkinson's disease. J Neurochem. 2010 Oct;115(1):178-87.
37. Fujita Y, Ihara M, Ushiki T, Hirai H, Kizaka-Kondoh S, Hiraoka M, Ito H, Takahashi R: Early protective effect of bone marrow mononuclear cells against ischemic white matter damage through augmentation of cerebral blood flow. Stroke. 2010 Dec;41(12):2938-43.
38. Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R: Nonhypotensive dose of telmisartan attenuates cognitive impairment partially due to peroxisome proliferator-activated receptor-gamma activation in mice with chronic cerebral hypoperfusion. Stroke. 2010 Aug;41(8):1798-806.
39. Honjo Y, Ito H, Horibe T, Takahashi R, Kawakami K: Protein disulfide isomerase-immunopositive inclusions in patients with Alzheimer disease. Brain Res. 2010 Aug 19;1349:90-6.
40. Nishio K, Ihara M, Yamasaki N, Kalaria RN, Maki T, Fujita Y, Ito H, Oishi N, Fukuyama H, Miyakawa T, Takahashi R, Tomimoto H: A mouse model characterizing features of vascular dementia with hippocampal atrophy. Stroke. 2010 Jun;41(6):1278-84.
41. Kawamoto Y, Ito H, Kobayashi Y, Suzuki Y, Akiguchi I, Fujimura H, Sakoda S, Kusaka H, Hirano A, Takahashi R: HtrA2/Omi-immunoreactive intraneuronal inclusions in the anterior horn of patients with sporadic and Cu/Zn superoxide dismutase (SOD1) mutant amyotrophic lateral sclerosis. Neuropathol Appl Neurobiol. 2010 Jun;36(4):331-44.
学位 平成6年11月 医学博士(京都大学 第1486号)
受賞 平成5年 木本新吉記念研究奨励賞
所属学会 日本神経学会 代議員
日本内科学会 評議員
日本神経病理学会 評議員
日本神経治療学会 評議員
日本臨床分子形態学会 評議員
日本神経科学学会
日本てんかん学会
日本脳卒中学会
日本定位・機能神経外科学会
日本パーキンソン病・運動障害疾患学会
日本免疫学会
日本CI学会
American Academy of Neurology
American Association of Neuropathologists
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