現在表示しているページ
ホーム > 大学案内 > 教育情報の公表 > 各教員が有する学位及び業績 > 教員情報(山上 裕機)
ここから本文です

教員情報

氏名 山上 裕機(ヤマウエ ヒロキ)
所属 外科学第2教室
職名 教授
連絡先
電話番号
073-441-0612
FAX番号
073-446-6566
E-mail
yamaue-h@wakayama-med.ac.jp
主な担当科目 消化器外科・内分泌・小児外科
主な研究テーマ 膵臓外科手術術式の開発
膵癌に対する2方向性ペプチドワクチン療法を応用した新規治療戦略
膵癌に対する網羅的遺伝子発現プロファイリングを応用した新規治療戦略としてのペプチド免疫療法の開発
研究分野 肝胆膵外科学
消化器外科学
腫瘍外科学
腫瘍免疫
癌免疫療法
遺伝子治療
略歴 1981年 3月 和歌山県立医科大学医学部 卒業
1981年 4月 和歌山県立医科大学附属病院診療医研修
1983年 4月 国立田辺病院外科勤務
1985年 4月 和歌山県立医科大学 臨床研究医(消化器外科学教室)
1985年11月 和歌山県立医科大学 助手(消化器外科学教室)
1991年 7月 和歌山県立医科大学 講師(消化器外科学教室)
1992年 9月 アメリカ国立医学研究所(NIH);国立がん研究所(NCI)腫瘍生物学部門
1994年 4月 和歌山県立医科大学 講師(外科学第2教室)
1999年 6月 和歌山県立医科大学附属病院 助教授(集学的治療・緩和ケア部)
2001年 6月 和歌山県立医科大学 教授(外科学第2教室)
2006年 4月 和歌山県立医科大学附属病院 副病院長 兼任
2010年 4月 和歌山県立医科大学 副学長 兼任
現在に至る
主な著書・論文 著書:
1. Kawai M, Yamaue H, et al: Pylorus RingResection Reduces Delayed Gastric Emptying in Patients UndergoingPancreatoduodenectomy: A Prospective Randomized Controlled Trial of Pylorus-Resecting Versus Pylorus-Preserving Pancreatoduodenectomy Ann Surg 253:1 7, 2011
2. Hayami S, Yamaue H, et al: Ponder BA, Nakamura Y, Hamamoto R: Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers.  Int J Cancer. 128(3):574-86, 2011
3. Matsuda K, Yamaue H, et al: Clinical impact of a macroscopically complete resection of colorectal cancer with peritoneal carcinomatosis. Surgery 2010 Dec 20 (Epub ahead of print]
4. Uchiyama K, Yamaue H, et al: Impact of nodal involvement on surgical outcomes of intrahepatic cholangiocarcinoma: a multicenter analysis by the Study Group for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepatobiliary Pancreat Sci. 2010 Dec 4. [Epub ahead of print]
5. Katai H, Yamaue H, et al: Safety and feasibility of laparoscopy-assisted distal gastrectomy with suprapancreatic nodal dissection for clinical stage I gastric cancer: a multicenter phase II trial (JCOG 0703). Gastric Cancer. 13(4):238-44, 2010
6. Kawai M, Yamaue H: Analysis of clinical trials evaluating complications after pancreaticoduodenectomy: a new era of pancreatic surgery. Surg Today. 40(11):1011-7, 2010
7. Iwahashi M, Yamaue H, et al: Vaccination with peptides derived from cancer-testis antigens in combination with CpG-7909 elicits strong specific CD8+ T cell response in patients with metastatic esophageal squamous cell carcinoma.  Cancer Sci. 101(12):2510-7, 2010
8. Shigekawa Y, Yamaue H, et al: Rectal obstruction by a giant pharmacobezoar composed of magnesium oxide: report of a case. Surgery Today. 40(10): 972-4, 2010
9. Uchiyama K, Yamaue H, et al: Combined Use of Contrast-Enhanced Intraoperative Ultrasonography and a Fluorescence Navigation System for Identifying Hepatic Metastases. World J Surg. 34(12):2953-9, 2010
10. Uchiyama K, Yamaue H, et al: Risk factors for postoperative infectious complications after hepatectomy. J Hepatobiliary Pancreat Sci. 2010 Jul 31. [Epub ahead of print]
11. Nishioka R, Yamaue H, et al: SNAIL induces epithelial-to-mesenchymal transition in a human pancreatic cancer cell line (BxPC3) and promotes distant metastasis and invasiveness in vivo. Exp Mol Pathol. 89(2): 149-57, 2010
12. Yoshikawa T, Yamaue H, et al: phase II study of preoperative chemotherapy with S-1 plus cisplatin followed by D2/D3 gastrectomy for clinically serosa-positive gastric cancer (JACCRO GC-01 study) EJSO 36:546-551, 2010
13. Shimamoto T, Yamaue H, et al: MUC1 Is A Useful Molecular Marker for Malignant Intraductal Papillary Mucinous Neoplasms in Pancreatic Juice Obtained from Endoscopic Retrograde Pancreatography Pancreas 39(6): 879-83, 2010
14. Hayami S, Yamaue H, et al: Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Mol Cancer. 9(1):59, 2010
15. Yokoyama S, Yamaue H, et al: Moderately differentiated colorectal adenocarcinoma as a lymph node metastatic phenotype: comparison with well differentiated counterparts. BMC Surg. 10:8, 2010
16. Kitahata Y, Yamaue H, et al: Hemangiopericytoma in the sacrococcygeal space: a case report. Journal of Medical Case Reports 4:8, 2010
17. Tani M, Yamaue H, et al: A prospective randomized controlled trial of internal versus external drainage with pancreaticojejunostomy for pancreaticoduodenectomy. Am J Surg. 199(6):759-64, 2010
18. Ina S, Yamaue H, et al: Identifying molecular markers for chemosensitivity to gemcitabine in pancreatic cancer: increased expression of Interferon stimulated gene 15kDa is associated with intrinsic chemoresistance. Pancreas 39(4):473-85, 2010
19. Miyazawa M, Yamaue H, et al: Phase I clinical trial using peptide vaccine for human vascular endothelial growth factor receptor 2 in combination with gemcitabine for patients with advanced pancreatic cancer. Cancer Sci. 101(2): 433-9, 2010
20. Ojima T, Yamaue H, et al: Clinicopathological Characteristics of Remnant Gastric Cancer After a Distal Gastrectomy. J Gastrointest Surg. 14(2): 277-81, 2010"
"21. Hirono S, Yamaue H, et al: Molecular markers associated with lymph node metastasis in pancreatic ductal adenocarcinoma by genome-wide expression profiling. Cancer Sci. 101(1): 259-66, 2010
22. Tominaga T, Yamaue H, et al: Combination of p53 codon 72 polymorphism and inactive p53 mutation predicts chemosensitivity to 5-fluorouracil in colorectal cancer. Int J Cancer. 126(7): 1691-701, 2010
23. Kawai M, Yamaue H, et al:The ratio between metastatic and examined lymph nodes is an independent prognostic factor for patients with resectable middle and distal bile duct carcinoma. Am J Surg 199(4): 447-52, 2010
24. Matsuda K, Yamaue H, et al:Clinicopathological features o f anastomotic recurrence after an anterior resection for rectal cancer. Langenbecks Arch Surg 395(3): 235-9, 2010
25. Hirono S, Yamaue H: Middle pancreatectomy for pancreatic neoplasms. J Hepatobiliary Pancreat Sci. 17(6): 803-7, 2010
26. Fujii R, Yamaue H, et al: Bacillus Calmette-Guerin cell-wall skeleton enhances the killing activity of cytotoxic lymphocyte-activated human dendritic cells transduced with the prostate-specific antigen gene. BJU Int. 104(11): 1766-73, 2009
27. Ueno M, Yamaue H, et al:New prediction model of postoperative complications after a major hepatectomy for hepatocellular carcinoma.  Dig Surg. 26(5): 392-399, 2009
28. Yokoyama S, Yamaue H, et al:C-Reactive protein is an independent surgical indication marker for appendicitis: a retrospective study. World J Emerg Surg. 4:36, 2009
29. Nakamura M, Yamaue H, et al:Reconstruction of an infected recurrent ventral hernia after a mesh repair using a pedicled tensor fascia lata flap: report of two cases. Surg Today 39(9): 811-7, 2009
30. Hayami S, Yamaue H, et al: Reconstruction of an infected recurrent ventral hernia after a mesh repair using a pedicled tensor fascia lata flap: report of two cases. Surg Today 39(9): 811-7, 2009
31. Kawai M, Yamaue H, et al:How Do We Predict the Clinically Relevant Pancreatic Fistula After Pancreaticoduodenectomy?-An Analysis in 244 Consecutive Patients. World J Surg 33(12): 2670-8. 2009
32. Ojima T, Yamaue H, et al:Association of Allogeneic Blood Transfusions and Long-Term Survival of Patients with Gastric Cancer after Curative Gastrectomy. J Gastrointest Surg 13(10): 1821-30, 2009
33. Ueno M, Yamaue H, et al:Prognostic impact of treatment modalities on patients with single nodular recurrence of hepatocellular carcinoma.Surgery Today Surg Today. 39(8): 675-81, 2009
34. Iwahashi M, Yamaue H, et al:Evaluation of Double Tract Reconstruction After Total Gastrectomy in Patients with Gastric Cancer: Prospective Randomized Controlled Trial. World J Surg 33(9): 1882-8, 2009
35. Hirono S, Yamaue H, et al:A central pancreatectomy for benign or low-grade malignant neoplasms. J Gastrointest Surg. 13(9): 1659-65, 2009
36. Tani M, Yamaue H, et al: pancreaticoduodenectomy is acceptable for periampullary tumors in the elderly, even in patients over 80 years of age. J Hepatobiliary Pancreat Surg. 16(5): 675-80, 2009
37. Ojima T, Yamaue H, et al:Influence of Overweight on Gastric Cancer Patients after Curative Gastrectomy: An analysis of 689 consecutive cases managed by a single center. Arch Surg. 144(4): 351-8, 2009
38. Hirono S, Yamaue H, et al:Treatment strategy for intraductal papillary mucinous neoplasm of the pancreas based on malignant predictive factors. Arch Surg. 144(4): 345-9, 2009
39. Ishida K, Yamaue H, et al: High CCR7 mRNA expression of cancer cells is associated with lymph node involvement in patients with esophageal squamous cell carcinoma. Int J Oncol. 34(4): 915-22, 2009
40. Kikkawa K, Yamaue H, et al: Dendritic cells with transduced survivin gene induce specific cytotoxic T lymphocytes in human urologic cancer cell lines.Urology. 74(1): 222-8, 2009
41. Tani M, Kawai M, Hirono S, Ina S, Miyazawa M, Fujita Y, Uchiyama K, Yamaue H: Pylorus-preserving pancreaticoduodenectomy versus conventional pancreaticoduodenectomy for pancreatic adenocarcinoma.. Surg Today. 39(3): 219-24, 2009
42. Uchiyama K, Yamaue H, et al: Xanthogranulomatous cholecystitis: The use of preoperative CT findings to differentiate it from gallbladder carcinoma. J Hepatobiliary Pancreat Surg. 16(3): 333-8, 2009
43. Hotta T, Yamaue H, et al: Risk factors and management for massive bleeding of an acute hemorrhagic rectal ulcer. Am Surg. 75(1): 66-73, 2009
44. Hotta T, Yamaue H, et al: Survival of patients with T3 stage III rectal cancer Is significantly worse than T2 stage III rectal cancer. A new proposal of a subdivision of stage III rectal cancer. Digestive Surg 26(1):69-74, 2009
45. Matsuda K, Yamaue H, et al: Long-term comorbidity of diabetes mellitus is a risk factor for perineal wound complications after an abdominoperineal resection. Langenbecks Arch Surg. 394(1): 65-70, 2009
46. Tani M, Yamaue H, et al: Liver metastasis as an initial recurrence has no impact on the survival of patients with resectable pancreatic adenocarcinoma. Langenbecks Arch Surg. 394(2):249-53, 2009
47. Uchiyama K, Yamaue H, et al: Half clamping of the infrahepatic inferior vena cava reduces bleeding during a hepatectomy by decreasing the central venous pressure. Langenbecks Arch Surg 394(2):243-7, 2009
48. Ueda K, Yamaue H, et al: Analysis of the prognostic factors and evaluation of surgical treatment for synchronous liver metastases from gastric cancer. Langenbecks Arch Surg 394(4): 647-53, 2009
49. Tani M, Yamaue H, et al: Early conversion from oral morphine to transdermal fentanyl in patients with cancer pain. Hepato-Gastroenterology 55(86-87):1545-8, 2008
50. Oku Y, Yamaue H, et al: Identification of the molecular mechanisms for dedifferentiation at the invasion front of colorectal cancer by a gene expression analysis. Clin Cancer Res. 14(22): 7215-22, 2008
51. Uchiyama K, Yamaue H, et al: Assessment of liver function for successful hepatectomy in patients with hepatocellular carcinoma with impaired hepatic function. J Hepatobiliary Pancreat Surg. 15(6): 596-602, 2008
52. Ina S, Yamaue H, et al: Phase Ⅱ trial of oral S-1 combined with low-dose cisplatin for unresectable advanced pancreatic cancer. Anticancer Res 28(4C): 2373-7, 2008
53. Tsuji T, Yamaue H, et al: Multiple early gastric cancer with gastritis cystica profunda showing various histological types.Hepatogastroenterology 55(84): 1150-2, 2008
54. Hirono S, Yamaue H, et al: A Collision tumor composed of cancers of the bile duct and ampulla of Vater - Immunohistochemical analysis of a rare entity of double cancer? Hepato-Gastroenterology 55(84): 861-4, 2008
55. Kawai M, Yamaue H, et al: Transection using bipolar scissors reduces pancreatic fistula afterdistal pancreatectomy. J Hepatobiliary Pancreat Surg 15(4): 366-72, 2008
56. Shono Y, Yamaue H, et al: Nonhepatocytic malignant mixed tumor of the liver in adults: report of a long surviving case. Int Surg 93(1): 55-8, 2008
57. Hama T, Yamaue H, et al: Laparoscopic splenectomy isa safe and effective procedure for patients with splenomegaly due to portal hypertension. J Hepatobiliary Pancreat Surg 15(3): 304-9, 2008
58. Tani M, Yamaue H, et al: Intraabdominal hemorrhage after a pancreatectomy. J Hepatobiliary Pancreat Surg 15(3): 257-61, 2008
59. Nakamori M, Yamaue H, et al: Laparoscopic resection of gastrointestinal stromal tumors of the stomach. Am J Surg 96(3): 425-9.2008
60. Naka T, Yamaue H, et al: Tumor vaccine therapy against recrudescent tumor using dendritic cells simultaneously transfected with tumor RNA and granulocyte macrophage colony-stimulating factor RNA. Cancer Sci 99(2): 407-13, 2008
61. Ojima T, Yamaue H, et al: Streptococcal preparation OK-432 promotes the capacity of dendritic cells (DCs) to prime carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocyte responses induced with genetically modified DCs that express CEA. Int J Oncol 32(2): 459-66, 2008
62. Nakamura M, Yamaue H, et al: An analysis of the factors contributing to a reduction in the incidence of pulmonary complications following an esophagectomy for esophageal cancer. Langenbecks Arch Surg 393(2): 127-33, 2008
63. Kawai M, Yamaue H, et al: CLIP method (preoperative CT image-assessed ligation of inferior pancreaticoduodenal artery) reduces intraoperative bleeding during pancreaticoduodenectomy. World J Surg 32(1): 82-87, 2008
学位 1989年4月 医学博士(和歌山県立医科大学 乙第405号)
受賞 優秀演題賞受賞(第1回国際胃癌学会,京都,1995)
所属学会 日本外科学会、日本消化器外科学会、日本肝胆膵外科学会、日本癌学会、日本癌治療学会、日本バイオセラピィ学会、アメリカ癌学会、国際外科学会、国際膵臓学会
社会貢献活動 和歌山県がん対策推進委員会委員
和歌山県がん診療連携協議会がん登録部会委員
和歌山県生活習慣病健診等管理指導協議会大腸がん部会専門委員