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Department of Pathology

Research

Department of Pathology was established in 1946. We currently specialize in experimental pathology, with a focus on research and education.
Our research interest is to elucidate the mechanisms of diseases, particularly cancer development, progression, and metastasis. Our research is conducted using a wide variety of methods, including biochemical, molecular, and cell biological methods, as well as histopathological examination. Not only cultured cell lines but also mouse models of disease are employed. Especially in cancer research, we are currently interested in research using several kinds of transplantation models.

Members

Shogo Ehata Professor Molecular mechanism of metastasis in renal cancer
Molecular mechanism of metastasis in sarcoma
TGF-β family signaling in cancer development
Kosuke Oikawa Lecturer Functional analysis of myxoid liposarcoma-specific chimeric oncorotein, TLS-CHOP
Analysis of tumor-related functions of cohesin regulator, WAPL
Masako Nakanishi Lecturer Mechanism of cancer bone metastasis
Tumor microenvironment in tumor progression
Takashi Ozaki Part-time Lecturer Development of thyroid
Effect of microwave
Rieko Tanibata Secretary  
Akiya Ibe Undergraduate  
Kiyoto Morishita Undergraduate  

Publications (2021~)

  • Sato F, Kohsaka A, Tanimoto T, Bhawal UK, Muragaki Y.
    Histological analysis of a Becker muscular dystrophy case, diurnal expression of dystrophin in control mice and decreased expression of dystrophin in Bmal1 knockout mice.
    Histol Histopathol. 2022 Jul 25:18499.
  • Ehata S, Miyazono K.
    Bone Morphogenetic Protein Signaling in Cancer; Some Topics in the Recent 10 Years.
    Front Cell Dev Biol. 2022 May 25;10:883523.
  • Nishida J, Miyakuni K, Miyazono K, Ehata S.
    An in vivo orthotopic serial passaging model for a metastatic renal cancer study.
    STAR Protoc. 2022 Apr 18;3(2):101306.
  • Sato F, Bhawal UK, Osaki S, Sugiyama N, Oikawa K, Muragaki Y.
    Differential immunohistochemical expression of DEC1, CK‑1ε, and CD44 in oral atypical squamous epithelium and carcinoma in situ.
    Mol Med Rep. 2022 May;25(5):159.
  • Kumagai K, Takanashi M, Ohno SI, Harada Y, Fujita K, Oikawa K, Sudo K, Ikeda SI, Nishi H, Oikawa K, Kuroda M.
    WAPL induces cervical intraepithelial neoplasia modulated with estrogen signaling without HPV E6/E7.
    Oncogene. 2021 May;40(21):3695-3706.
  • Murakami D, Kono M, Nanushaj D, Kaneko F, Zangari T, Muragaki Y, Weiser JN, Hotomi M.
    Exposure to Cigarette Smoke Enhances Pneumococcal Transmission Among Littermates in an Infant Mouse Model.
    Front Cell Infect Microbiol. 2021 Mar 31;11:651495.
  • Nakanishi M, Korechika A, Yamakawa H, Kawabe N, Nakai K, Muragaki Y.
    Acidic microenvironment induction of interleukin-8 expression and matrix metalloproteinase-2/-9 activation via acid-sensing ion channel 1 promotes breast cancer cell progression.
    Oncol Rep. 2021 Mar;45(3):1284-1294.
  • Ono K, Hata K, Nakamura E, Ishihara S, Kobayashi S, Nakanishi M, Yoshida M, Takahata Y, Murakami T, Takenoshita S, Komori T, Nishimura R, Yoneda T.
    Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2.
    Commun Biol. 2021 Mar 11;4(1):326.
  • Enaka M, Nakanishi M, Muragaki Y.
    The Gain-of-Function Mutation p53R248W Suppresses Cell Proliferation and Invasion of Oral Squamous Cell Carcinoma through the Down-Regulation of Keratin 17.
    Am J Pathol. 2021 Mar;191(3):555-566.