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Second Department of Physiology
We held Satellite Symposium of the 5th Congress of the International Society for Autonomic Neuroscience (ISAN 2007) --- New Insights into Central Control Mechanisms of Circulation --- on October 3, 2007 at Hotel Granvia Wakayama, Wakayama City, JAPAN.
The faculty and staff of our department at the Satellite Symposium of the 5th Congress of the International Society for Autonomic Neuroscience (ISAN 2007) --- New Insights into Central Control Mechanisms of Circulation --- on October 3, 2007 at Hotel Granvia Wakayama, Wakayama City, JAPAN.
The 5th Congress of the International Society for Autonomic Neuroscience (ISAN 2007) in Kyoto.
We held the meeting for the Circulatory Physiology at the 84th Annual Meeting of the Physiological Society of Japan on May 20, 2007.
FACULTY AND STAFF
|Professor||Masanobu MAEDA, M.D., Ph.D.
Council member of the Physiological Society of Japan,
|Associate Professor||Akira KOHSAKA, M.D., Ph.D.|
|Instructor||Tsuyoshi OTSUKA, Ph.D.|
|Instructor||Hue LE Thi, M.D.
(Hanoi Medical University, Vietnam)
|Instructor||Tomomi NAKAO, M.D.|
|Instructor||Zaw Lin THEIN, M.D., Ph.D.
(University of Medicine 1, Yangon, Myanmar)
|Post-doctoral Fellow||Shigeo KUSUMOTO, M.D., Ph.D.|
|Graduate Researcher||Toshiya YAMAZAKI|
|Graduate (PhD) Student
|Tomomi NAKAO, M.D. (Instructor)|
|Graduate (PhD) Student
|Hue LE Thi, M.D. (Instructor)|
Department of Physiology,
Wakayama Medical University School of Medicine,
811-1, Kimiidera, Wakayama City, 641-8509, Japan
Telephone +81-73-441-0623 (Office of Department)
Fax +81-73-441-0623 (Office of Department)
School of Medicine
Lectures; 100 hours
Practice; 40 hours
The subject matter of physiology is the foundation of the practice of medicine, and a firm grasp of its principles is essential for the practicing physician. In this course, we present the physiological functions of the human body in a way that the medical students can understand intricate mechanisms and control systems which normally allow all parts of the body to function in harmony. We explain the functions of the autonomic nervous system, cardiovascular physiology, respiratory physiology, renal physiology, endocrine physiology, and so on.
Graduate School of Medicine
In Doctor’s Course of Graduate School of Medicine, the name of this laboratory is Division of Integrative and Molecular Physiology, Department of Physiological Sciences, Field of Structural and Functional Biomedical Sciences. We teach integrative physiology, molecular and cellular physiology, physiology of autonomic nervous system and circulatory physiology to the graduate students of Doctor’s Course. The graduate students perform the experimental study for integrative and molecular physiology under us.
In Master’s Course of Graduate School of Medicine, the name of this laboratory is Division of Integrative and Molecular Physiology, Field of Medical Sciences. We teach human structural and functional biomedical sciences, integrative molecular physiology and so on to the graduate students of Master’s Course. The graduate students perform the experimental study for integrative and molecular physiology under us.
Physiology is an integrative discipline that includes the study of molecules and subcellular components of the body, cells, tissues, organ systems, and interactions between all of these parts in health and in disease. In this laboratory, we investigate the function applying molecular biology to physiology. According to the rapid development of molecular biology, physiology is also changing largely. We aim at the wide research that both molecular mechanisms and integrative functions are taken into consideration. And we have a dream of protein treatment of various diseases using protein direct in vivo transduction into the brain.
MAJOR RESEARCH INTERESTS
- Central control mechanisms of circulation: effects of microinjection of new peptides into the brain on blood pressure, heart rate and local blood flow.
- Changes of the body function when the protein is transducted into the brain or the heart in vivo.
- Circadian rhythm and obesity.
Brain sections from rats microinjected with b-galactosidase (b-gal) protein using hemagglutinating virus of Japan envelope (HVJ-E) vector. Note the strong b-gal activity (A). X-Gal-stained neurons are seen at the site of microinjection (B). Arrows point to X-Gal-stained neuronal cells. CC, central canal. Scale bars, 100µm.
To the best of our knowledge, this paper is the first report of direct in vivo protein transduction into a specific restricted brain area.
SELECTED PUBLICATIONS IN ENGLISH (2000 ~ 2007)
- Maeda, M., Waki, H., Kohsaka, A., Yukawa, K., Nakamura, T.: The Sympathoexcitatory Pathway from the CVL to the RVL for Controlling Brain Vessels. Tzu Chi Ned J, 2008, in press
- Waki, H., Yamasaki, M., Katahira, K., Katsuda, S., Maeda, M., Shimizu, T.: Developmental changes in functional characteristics of aortic baroreceptor afferents in rats. Experimental Physiology, 93 (3): 319-324, 2008.
- Maeda, M.: Chapter 11 Regulation of local blood flows by the cardiovascular center and new strategy for central regulation of circulation. In Kubo, T., Kuwaki, T. (eds.) Central mechanisms of cardiovascular regulation. Transworld Research Network, India, 2007, pp. 173-193. (Invited paper, Review book)
- Duale H, Waki H, Howorth P, Kasparov S, Teschemacher AG, Paton JFR: Restraining influence of A2 neurons in chronic control of arterial pressure in spontaneously hypertensive rats. Cardiovasc Res 76: 184-193, 2007
- Paton JFR, Waki H, Abdala AP, Dickinson J, Kasparov S: Vascular-brain signaling in hypertension: role of angiotensin II and nitric oxide. Curr Hypertens Rep 9: 242-247, 2007
- Waki H, Kasparov S, Liu B, Miyake M, Katahira K, Murphy D, Paton JFR: Junctional adhesion molecule-1 is up regulated in the spontaneously hypertensive rat: evidence for a pro-hypertensive role within the brainstem. Hypertension 49: 1-7, 2007
- St-John WM, Waki H, Dutschmann M, Paton JFR: Maintenance of eupnea of in situ and in vivo rats following riluzole: a blocker of persistent sodium channels. Respir Physiol Neurobiol. 15, 155(1):97-100, 2007
- Tanaka T, Yukawa K, Umesaki N: Radiation reduces bleomycin sensitivity in cervical squamous cancer cells in vitro. Eur J Gynaec Oncol XXVIII, n.4: 273-277, 2007
- Tanaka T, Yukawa K, Umesaki N: Radiation reduces carboplatin sensitivity and enhances nedaplatin sensitivity in cervical squamous cell carcinoma in vitro. Eur J Gynaec Oncol XXVIII, n.5: 352-355, 2007
- Kohsaka A, Laposky A, Moynihan Ramsey K, Estrada C, Joshu C, Kobayashi Y, Turek FW, Bass J: High Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice.
Cell Metabolism 6: 414-21, 2007
- McClurg P, Janes J, Wu C, Delano DL, Walker JR, Batalov S, Takahashi JS, Shimomura K, Kohsaka A, Bass J, Wiltshire T, Su AI: Genome-wide Association Analysis in Diverse Inbred Mice: Power and Population Structure. Genetics 176: 675-83, 2007
- Gouraud SS, Heesom K, Yao ST, Qiu J, Paton JFR, Murphy D: Dehydration-induced proteome changes in the rat hypothalamo-neurohypophyseal system. Endocrinology. 148 (7):3041-52, 2007
- Gouraud SS, Yao ST, Heesom KJ, Paton JFR, Murphy D: 14-3-3 proteins within the hypothalamic-neurohypophyseal system of the osmotically stressed rat: transcriptomic and proteomic studies. J Neuroendocrinol. 19 (11) : 913-22, 2007
- Waki H, Paton JFR: Response to Junctional Adhesion Molecule-1 May Have a Wider Role in Cardiovascular Disease. Hypertension 50:e23,doi:10.1161/HYPERTENSIONAHA.107.093195, 2007
- Kohsaka A , Bass J: A Sense of Time: How Molecular Clocks Organize Metabolism.
Trends Endocrinol Metab 18:4-11, 2007
- Moynihan Ramsey K, Marcheva B, Kohsaka A, Bass J: The Clockwork of Metabolism.
Annu Rev Nutr 27:219-40, 2007
- Yukawa K, Tanaka T, Bai T, Li L, Tsubota Y, Owada-Makabe K, Maeda M, Hoshino K, Akira S, Iso H: Deletion of the kinase domain from death-associated protein kinase enhances spatial memory in mice.
Int J Mol Med 17(5):869-73, 2006
- Tanaka T, Yukawa K, Umesaki N: Effective chemoradiotherapy protocol with 5-fluorouracil for cervical squamous cell carcinoma in vitro.
Eur J Gynaec Oncol 2006 XXVII, n. 3: 243-246, 2006
- Tanaka T, Bai T, Yukawa K, Umesaki N: Optimal combination chemotherapy and chemoradiotherapy with etoposide for advanced cervical squamous cancer cells in vitro.
Oncol Rep 15(4):939-47,2006
- Bai T, Tanaka T, Yukawa K, Umesaki N, Matsumoto M, Akira S: Impaired postnatal development in C/EBPβ-deficient mice.
The Journal of Reproduction and Developement, 52(5): 645-9, 2006.
- Bai T, Tanaka T, Yukawa K, Umesaki N: A novel mechanism for acquired cisplatin-resistance: Suppressed translation of death-associated protein kinase mRNA is insensitive to 5-aza-2'-deoxycitidine and trichostatin in cisplatin-resitant cervical squamous cancer cells.
Int J Oncol 28(2):497-508, 2006
- Waki H, Kasparov S, Murphy D, Paton JF: Endothelial nitric oxide synthase in nucleus tractus solitarii contributes to hypertension in spontaneously hypertensive rats.
Hypertension 48: 644-650, 2006
- Polson J, McCallion N, Waki H, Thorne G, Tooley M, Paton JF, Wolf A: Evidence for cardiovascular autonomic dysfunction in neonates withcoarctation of the aorta.
Circulation, 113: 2844-2850, 2006
- Waki H, Katahira K, Polson JW, Kasparov S, Murphy D, Paton JF: Automation of analysis of cardiovascular autonomic function from chronic measurements of arterial pressure in conscious rats. Exp Physiol 91: 201-213, 2006
- Owada-Makabe K, Tsubota Y, Yukawa K, Kakimoto N, Ling X.-M, Ichinose M, Maeda M : Direct in vivo protein transduction into a specific restricted brain area in rats.
Neurosci Lett 378(1) : 18-21, 2005
- Tsubota Y, Owada-Makabe K, Yukawa K, Maeda M : Hypotensive effect of des-acyl ghrelin at uncleus tractus solitarii of rat.
NeuroReport 16(2) : 163-6, 2005
- Yukawa K, Kishino M, Hoshino K, Shirasawa N, Kimura A, Tsubota Y, Owada-Makabe K,
Bai T, Tanaka T, Ueyama T, Ichinose M, Takeda K, Akira S, Maeda M : The kinase domain of death-associated protein kinase is inhibitory for tubulointerstitial fibrosis in chronic obstructive nephropathy.
Int J Mol Med 15 (1) : 73-8, 2005.
- Yukawa K, Kishino M, Goda M, Ling X.-M, Kimura A, Tanaka T, Bai T, Owada-Makabe K, Tsubota Y, Ueyama Y, Ichinose M, Maeda M, Takeda K, Akira S : STAT6 deficiency inhibits tubulointerstitial fibrosis in obstructive nephropathy.
Int J Mol Med 15 (2 ) : 225-30, 2005.
- Kumanogoh A, shikina T, Suzuki K, Uematsu S, Yukawa K, Kashiwamura S, Tsutsui H, Yamamoto M, Takamatu H, Ko-Mitamura EP, Takegahara N, Marukawa S, Ishida I, Morishita H, Prasad DV, Tamura M, Mizui M, Toyofuku T, Akira S, Takeda K, Okabe M, Kikutani H : Nonredundant roles of Sema4A in the immune system: defective T cell priming and TH1/TH2 regulation in Sema4A-deficient mice.
Immunity 22(3) : 305-16, 2005
- Yukawa K, Iso H, Tanaka T, Tsubota Y, Owada-Makabe K, Bai T, Takeda K, Akira S, Maeda M : Down-regulation of dopamine transporter and abnormal behavior in STAT6-deficient mice.
Int J Mol Med 15(5) : 819-25, 2005
- Yukawa K, Tanaka T, Bai T, Ueyama T, Owada-Makabe K, Tsubota Y, Maeda M, Suzuki K, Kikutani H, Kumanogoh A : Semaphorin 4A induces growth cone collapse of hippocampal neurons in a Rho/Rho-kinase-dependent manner.
Int J Mol Med 16(1) : 115-8, 2005
- Yukawa K, Hoshino K, Kishino M, Tsubota Y, Owada-Makabe K, Maeda M, Bai T, Tanaka T , Akira S : Deletion of the kinase domain from death-associated protein kinase attenuates p53 expression in chronic obstructive uropathy.
Int j Mol Med 16(3) : 389-93, 2005
- Tanaka T, Yukawa K, Umesaki N : Radiation enhances cisplatin-sensitivity in human cervical squamous cancer cells in vitro.
Eur J Gynaecol Oncol 26(4) :431-3, 2005
- Tanaka T, Bai T, Yukawa K, Utsunomiya T, Umesaki N : Reduced radiosensitivity and increased CD40 expression in cyclophosphamide-resistant subclones established from human cervical squamous cell carcinoma cells.
Oncol Rep 14(4) :941-8, 2005
- Tanaka T, Bai T, Yukawa K, Umesaki N : Radiation-induced cell death is independent of the apoptotic signals mediated by death-associated protein kinase in human cervical squamous cell carcinoma cells.
Oncol Rep 14(4) :949-55, 2005
- Yukawa K, Tanaka T, Owada-Makabe K, Tsubota Y, Bai T, Maeda M, Takeda K, Akira S, Iso H : Reduced prepulse inhibition of startle in STAT6-deficient mice.
Int j Mol Med 16(4) : 673-5, 2005
- Tanaka T, Toujima S, Utsunomiya T, Bai T, Utsunomiya H, Mori I, Yukawa K, Umesaki N :
Cell proliferation of bulky cervical squamous cell carcinoma is strongly associated with a parecrine tissue-specific growth factor(s).
Oncol Rep 14(5) :1121-6, 2005
- Tanaka T, Yukawa K, Umesaki N : Combination effwcts of irradiation and irinotecan on cervical squamous cell carcinoma cells in vitro.
Oncol Rep 14(5) : 1365-9, 2005
- Kakimoto N : Hypotensiv effect of neuromedin U by microinjection into the rat cardiovascular-related region of the medulla oblongata.
財団法人循環器学研究進行財団 平成16年度事業報告書 : 62-65, 2005
- Bai T, Tanaka T, Yukawa K, Maeda M, Umesaki N : Reduced expression of death-associated protein kinase in human uterine and ovarian carcinoma cells.
Oncol Rep 11 (3): 661-665, 2004
- Yukawa K, Hoshino K, Kishino M, Mune M, Shirasawa N, Kimura A, Tsubota Y, Owada-Makabe K, Tanaka T, Ichinose M, Maeda M, Takeda K, Akira S : Deletion of the kinase domain in death-associated protein kinase attenuates renal tubular cell apoptosis in chronic obstructive uropathy.
Int J Mol Med 13 (4): 515-520, 2004.
- Yukawa K, Shirasawa N, Ohshima A, Mune M, Kimura A, Bai T, Tsubota Y, Owada-Makabe K, Tanak T, Kishino M, Tsuruo Y, Umesaki N, Maeda M : Localization of Death-associated protein kinase to renal tubule cells, and increased expression in rat chronic obstructive uropathy.
J Nephrol 17 (1): 26-33, 2004.
- Kishino M*, Yukawa K*, Hoshino K*, Kimura A, Shirasawa N, Otani H, Tanaka T, Owada-Makabe K, Tsubota Y, Maeda M, Ichinose M, Takeda K, Akira S, Mune M : (*equally contriduted) Deletion of the kinase domain in death-associated protein kinase attenuates tubular cell apoptosis in renal ischemia-reperfusion injury.
J Am Soc Nephrol 15 (7): 1826-1834, 2004.
- Tsubota Y, Miyashita E, Miyajima M, Owada-Makabe K, Yukawa K, Maeda M: The Wakayama Epileptic Rat (WER), a new mutant exhibiting tonic-clonic seizures and absence-like seizures. Exp Anim, 52 (1): 53-62, 2003.
- Inoue M, Maeda M, Washio M, Harada N: Occupational health laws in Japan and various other countries: comparison for identification of specific shortcomings in Japan. Int Med J, 10 (1): 7-11, 2003.
- Maeda M, Tsubota Y, Owada-Makabe K, Yukawa K, Kakimoto N: Regulation of local blood flow by the cardiovascular center and changes of circulattion by the microinjection of antisense oligonucleotide into the cardiovascular center of the medulla. Clin Exp Hypertens, 25 (5): 295-296, 2003.
- Tsubota Y, Kakimoto N, Owada-Makabe K, Yukawa K, Liang X.-M, Mune M, Maeda M: Hypotensive effects of neuromedin U microinjected into the cardiovascular-related region of the rat uncleus tractus solitarius. NeuroReport, 114 (18): 2387-2390, 2003
- Yamanashi K, Miyamae T, Sasaki Y, Maeda M, Hirano H, Misu Y, Goshima Y: Involvement of nitric oxide production via kynurenic acid-sensitive glutamate receptors in DOPA-induced depressor responses in the nucleus tractus solitarii of anesthetized rats. Neuroscience Research 43: 231-238, 2002
- Nishino T, Kudo H, Doi Y, Meada M, Hamasaki K, Morita M, Fujimoto S : Immunocytochemistry of glutathione S-transferase in taste bud cells of rat circumvallate and foliate papillae. Chemical Senses, 26 (2): 179-188, 2001
- Irie M, Meada M, Nagata S : Can conditioned histamine release occur under urethane anesthesia in guinea pigs ?
Physiology & Behavior, 72 (4): 567-573, 2001
- Murata H, Yamazaki S, Maeda M, Hisashige A : Input-output analysis of economic effect in nursing care insurance. Journal of Home Economics of Japan, 52 (8): 729-736, 2001
- Inoue M, Minami Y, Masaki S, Kawashita T, Yoshioka K, Maeda M : Attitudes toward reports on general health examination results by age, judgement of findings and work-styles. Journal of Occupational Health, 43 (5): 281-283, 2001
- Nakai M, Maeda M: Cerebral cortical muscarinic cholinergic and N-methyl-D-aspartate receptors mediate increase in cortical blood flow elicited by chemical stimulation of periaqueductal gray matter. Neuroscience 98 (3): 449-457, 2000
- Washio M, Ishibashi N, Arai Y, Kiyohara C, Tanaka K, Maeda M, Fujishima M, Okayama M : The isolation of Methicillin-resistant Staphylococcus aureus (MRSA) is a predictor for poor prognosis of the elderly patients with bacterial infection. International Medical Journal 7 (2): 117-120, 2000
- Yukawa K, Tanaka T, Toyomi A, Tsuji S, Akira S, Iso H: Impairedwater-maze performance in mice lacking trenscription factor DDAAT/enhancer-cription facter C/ATF by the cAMP signal activation in hippocampal neurons,binding protein β. Neuroscience research Communicatons 26:59-67, 2000
- Shi W, Kumanogoh A, Watanabe C, Uchida J, Wang X, Yasui T, Yukawa K, Ikawa M, Okabe M, Parnes J R, Yoshida K, Kikutani H : The Class IVSemaphorin CD100 Plays Noruredant Roles in thelmmune S ystem: Defective B and T Cell Activationin CD100-Deficient Mice. Immunity 13: 633-642, 2000
- Maeda M, Inoue M, Washio M : International comparison of periodic health examination and medical privacy of workers. Journal of UOEH 22 (Supplement): 165-168, 2000
- Inoue M, Maeda M : Effect of different work styles on blood pressure. Journal of UOEH 22 (Supplement): 197-200, 2000
- Maeda M : Physiological mechanisms of job stress. Lecture note on occupational health, 2000
Published by Japan International Cooperation Agency and University of Occupational and Environmental Health, Kitakyushu, Japan. pp. 317-320, 2000